Shimma N - Search Results

1

Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors.

Asoh K, Kohchi M, Hyoudoh I, Ohtsuka T, Masubuchi M, Kawasaki K, Ebiike H, Shiratori Y, Fukami TA, Kondoh O, Tsukaguchi T, Ishii N, Aoki Y, Shimma N, Sakaitani M. Asoh K, et al. Among authors: shimma n. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1753-7. doi: 10.1016/j.bmcl.2009.01.074. Epub 2009 Feb 11. Bioorg Med Chem Lett. 2009. PMID: 19217288

2

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2.

Ebiike H, Masubuchi M, Liu P, Kawasaki K, Morikami K, Sogabe S, Hayase M, Fujii T, Sakata K, Shindoh H, Shiratori Y, Aoki Y, Ohtsuka T, Shimma N. Ebiike H, et al. Among authors: shimma n. Bioorg Med Chem Lett. 2002 Feb 25;12(4):607-10. doi: 10.1016/s0960-894x(01)00808-3. Bioorg Med Chem Lett. 2002. PMID: 11844682

3

Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors.

Sogabe S, Masubuchi M, Sakata K, Fukami TA, Morikami K, Shiratori Y, Ebiike H, Kawasaki K, Aoki Y, Shimma N, D'Arcy A, Winkler FK, Banner DW, Ohtsuka T. Sogabe S, et al. Among authors: shimma n. Chem Biol. 2002 Oct;9(10):1119-28. doi: 10.1016/s1074-5521(02)00240-5. Chem Biol. 2002. PMID: 12401496

4

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.

Kawasaki K, Masubuchi M, Morikami K, Sogabe S, Aoyama T, Ebiike H, Niizuma S, Hayase M, Fujii T, Sakata K, Shindoh H, Shiratori Y, Aoki Y, Ohtsuka T, Shimma N. Kawasaki K, et al. Among authors: shimma n. Bioorg Med Chem Lett. 2003 Jan 6;13(1):87-91. doi: 10.1016/s0960-894x(02)00844-2. Bioorg Med Chem Lett. 2003. PMID: 12467623

5

Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole.

Ohwada J, Tsukazaki M, Hayase T, Oikawa N, Isshiki Y, Fukuda H, Mizuguchi E, Sakaitani M, Shiratori Y, Yamazaki T, Ichihara S, Umeda I, Shimma N. Ohwada J, et al. Among authors: shimma n. Bioorg Med Chem Lett. 2003 Jan 20;13(2):191-6. doi: 10.1016/s0960-894x(02)00892-2. Bioorg Med Chem Lett. 2003. PMID: 12482421

6

Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase.

Masubuchi M, Ebiike H, Kawasaki K, Sogabe S, Morikami K, Shiratori Y, Tsujii S, Fujii T, Sakata K, Hayase M, Shindoh H, Aoki Y, Ohtsuka T, Shimma N. Masubuchi M, et al. Among authors: shimma n. Bioorg Med Chem. 2003 Oct 1;11(20):4463-78. doi: 10.1016/s0968-0896(03)00429-2. Bioorg Med Chem. 2003. PMID: 13129583

7

Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.

Isshiki Y, Kohchi Y, Iikura H, Matsubara Y, Asoh K, Murata T, Kohchi M, Mizuguchi E, Tsujii S, Hattori K, Miura T, Yoshimura Y, Aida S, Miwa M, Saitoh R, Murao N, Okabe H, Belunis C, Janson C, Lukacs C, Schück V, Shimma N. Isshiki Y, et al. Among authors: shimma n. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1795-801. doi: 10.1016/j.bmcl.2011.01.062. Epub 2011 Jan 21. Bioorg Med Chem Lett. 2011. PMID: 21316218

8

Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799.

Ohwada J, Ebiike H, Kawada H, Tsukazaki M, Nakamura M, Miyazaki T, Morikami K, Yoshinari K, Yoshida M, Kondoh O, Kuramoto S, Ogawa K, Aoki Y, Shimma N. Ohwada J, et al. Among authors: shimma n. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1767-72. doi: 10.1016/j.bmcl.2011.01.065. Epub 2011 Jan 22. Bioorg Med Chem Lett. 2011. PMID: 21316229

9

Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design.

Miura T, Fukami TA, Hasegawa K, Ono N, Suda A, Shindo H, Yoon DO, Kim SJ, Na YJ, Aoki Y, Shimma N, Tsukuda T, Shiratori Y. Miura T, et al. Among authors: shimma n. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5778-83. doi: 10.1016/j.bmcl.2011.08.001. Epub 2011 Aug 6. Bioorg Med Chem Lett. 2011. PMID: 21875802

10

Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors.

Suda A, Koyano H, Hayase T, Hada K, Kawasaki K, Komiyama S, Hasegawa K, Fukami TA, Sato S, Miura T, Ono N, Yamazaki T, Saitoh R, Shimma N, Shiratori Y, Tsukuda T. Suda A, et al. Among authors: shimma n. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1136-41. doi: 10.1016/j.bmcl.2011.11.100. Epub 2011 Dec 1. Bioorg Med Chem Lett. 2012. PMID: 22192591

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