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Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.
Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, Lee BH, Roesel JL, Karsenty G, Hanauer A, Taunton J, Boggon TJ, Gu TL, Chen J. Kang S, et al. Among authors: taunton j. Mol Cell Biol. 2009 Apr;29(8):2105-17. doi: 10.1128/MCB.00998-08. Epub 2009 Feb 17. Mol Cell Biol. 2009. PMID: 19223461 Free PMC article.
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun SY, Marcus AI, Gu TL, Polakiewicz RD, Chen ZG, Khuri FR, Shin DM, Chen J. Kang S, et al. Among authors: taunton j. J Clin Invest. 2010 Apr;120(4):1165-77. doi: 10.1172/JCI40582. Epub 2010 Mar 15. J Clin Invest. 2010. PMID: 20234090 Free PMC article.
The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis.
Li D, Jin L, Alesi GN, Kim YM, Fan J, Seo JH, Wang D, Tucker M, Gu TL, Lee BH, Taunton J, Magliocca KR, Chen ZG, Shin DM, Khuri FR, Kang S. Li D, et al. Among authors: taunton j. J Biol Chem. 2013 Nov 8;288(45):32528-32538. doi: 10.1074/jbc.M113.500561. Epub 2013 Oct 1. J Biol Chem. 2013. PMID: 24085294 Free PMC article.
RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity.
Lee S, Shuman JD, Guszczynski T, Sakchaisri K, Sebastian T, Copeland TD, Miller M, Cohen MS, Taunton J, Smart RC, Xiao Z, Yu LR, Veenstra TD, Johnson PF. Lee S, et al. Among authors: taunton j. Mol Cell Biol. 2010 Jun;30(11):2621-35. doi: 10.1128/MCB.00782-09. Epub 2010 Mar 29. Mol Cell Biol. 2010. PMID: 20351173 Free PMC article.
betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.
Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J, Pagano M. Dehan E, et al. Among authors: taunton j. Mol Cell. 2009 Jan 16;33(1):109-16. doi: 10.1016/j.molcel.2008.12.020. Mol Cell. 2009. PMID: 19150432 Free PMC article.
258 results