Schwartz GK - Search Results

1

Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780.

Nair JS, Ho AL, Tse AN, Coward J, Cheema H, Ambrosini G, Keen N, Schwartz GK. Nair JS, et al. Among authors: schwartz gk. Mol Biol Cell. 2009 Apr;20(8):2218-28. doi: 10.1091/mbc.e08-08-0885. Epub 2009 Feb 18. Mol Biol Cell. 2009. PMID: 19225156 Free PMC article.

2

Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells.

Motwani M, Li X, Schwartz GK. Motwani M, et al. Among authors: schwartz gk. Clin Cancer Res. 2000 Mar;6(3):924-32. Clin Cancer Res. 2000. PMID: 10741717

3

Huanglian, A chinese herbal extract, inhibits cell growth by suppressing the expression of cyclin B1 and inhibiting CDC2 kinase activity in human cancer cells.

Li XK, Motwani M, Tong W, Bornmann W, Schwartz GK. Li XK, et al. Among authors: schwartz gk. Mol Pharmacol. 2000 Dec;58(6):1287-93. doi: 10.1124/mol.58.6.1287. Mol Pharmacol. 2000. PMID: 11093765

4

Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe.

Tse AN, Schwartz GK. Tse AN, et al. Among authors: schwartz gk. Cancer Res. 2004 Sep 15;64(18):6635-44. doi: 10.1158/0008-5472.CAN-04-0841. Cancer Res. 2004. PMID: 15374978

5

Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.

Chung KY, Shia J, Kemeny NE, Shah M, Schwartz GK, Tse A, Hamilton A, Pan D, Schrag D, Schwartz L, Klimstra DS, Fridman D, Kelsen DP, Saltz LB. Chung KY, et al. Among authors: schwartz gk, schwartz l. J Clin Oncol. 2005 Mar 20;23(9):1803-10. doi: 10.1200/JCO.2005.08.037. Epub 2005 Jan 27. J Clin Oncol. 2005. PMID: 15677699

6

Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells.

Sambol EB, Ambrosini G, Geha RC, Kennealey PT, Decarolis P, O'connor R, Wu YV, Motwani M, Chen JH, Schwartz GK, Singer S. Sambol EB, et al. Among authors: schwartz gk. Cancer Res. 2006 Jun 1;66(11):5858-66. doi: 10.1158/0008-5472.CAN-05-2933. Cancer Res. 2006. PMID: 16740725

7

Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma.

Shah MA, Ramanathan RK, Ilson DH, Levnor A, D'Adamo D, O'Reilly E, Tse A, Trocola R, Schwartz L, Capanu M, Schwartz GK, Kelsen DP. Shah MA, et al. Among authors: schwartz l, schwartz gk. J Clin Oncol. 2006 Nov 20;24(33):5201-6. doi: 10.1200/JCO.2006.08.0887. J Clin Oncol. 2006. PMID: 17114652 Clinical Trial.

8

Aurora kinases: new targets for cancer therapy.

Carvajal RD, Tse A, Schwartz GK. Carvajal RD, et al. Among authors: schwartz gk. Clin Cancer Res. 2006 Dec 1;12(23):6869-75. doi: 10.1158/1078-0432.CCR-06-1405. Clin Cancer Res. 2006. PMID: 17145803 Review.

9

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

Ambrosini G, Sambol EB, Carvajal D, Vassilev LT, Singer S, Schwartz GK. Ambrosini G, et al. Among authors: schwartz gk. Oncogene. 2007 May 24;26(24):3473-81. doi: 10.1038/sj.onc.1210136. Epub 2006 Dec 4. Oncogene. 2007. PMID: 17146434

10

CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo.

Tse AN, Rendahl KG, Sheikh T, Cheema H, Aardalen K, Embry M, Ma S, Moler EJ, Ni ZJ, Lopes de Menezes DE, Hibner B, Gesner TG, Schwartz GK. Tse AN, et al. Among authors: schwartz gk. Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):591-602. doi: 10.1158/1078-0432.CCR-06-1424. Clin Cancer Res. 2007. PMID: 17255282

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