Sweeny EA - Search Results

1

Prion proteostasis: Hsp104 meets its supporting cast.

Sweeny EA, Shorter J. Sweeny EA, et al. Prion. 2008 Oct-Dec;2(4):135-40. doi: 10.4161/pri.2.4.7952. Epub 2008 Oct 22. Prion. 2008. PMID: 19242125 Free PMC article. Review.

2

A synergistic small-molecule combination directly eradicates diverse prion strain structures.

Roberts BE, Duennwald ML, Wang H, Chung C, Lopreiato NP, Sweeny EA, Knight MN, Shorter J. Roberts BE, et al. Among authors: sweeny ea. Nat Chem Biol. 2009 Dec;5(12):936-46. doi: 10.1038/nchembio.246. Epub 2009 Nov 1. Nat Chem Biol. 2009. PMID: 19915541 Free PMC article.

3

Purification of hsp104, a protein disaggregase.

Sweeny EA, DeSantis ME, Shorter J. Sweeny EA, et al. J Vis Exp. 2011 Sep 30;(55):3190. doi: 10.3791/3190. J Vis Exp. 2011. PMID: 21989490 Free PMC article.

4

Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.

DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J. DeSantis ME, et al. Among authors: sweeny ea. Cell. 2012 Nov 9;151(4):778-793. doi: 10.1016/j.cell.2012.09.038. Cell. 2012. PMID: 23141537 Free PMC article.

5

Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation.

Desantis ME, Sweeny EA, Snead D, Leung EH, Go MS, Gupta K, Wendler P, Shorter J. Desantis ME, et al. Among authors: sweeny ea. J Biol Chem. 2014 Jan 10;289(2):848-67. doi: 10.1074/jbc.M113.520759. Epub 2013 Nov 26. J Biol Chem. 2014. PMID: 24280225 Free PMC article.

6

The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation.

Sweeny EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, Shorter J. Sweeny EA, et al. Mol Cell. 2015 Mar 5;57(5):836-849. doi: 10.1016/j.molcel.2014.12.021. Epub 2015 Jan 22. Mol Cell. 2015. PMID: 25620563 Free PMC article.

7

Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104.

Sweeny EA, Shorter J. Sweeny EA, et al. J Mol Biol. 2016 May 8;428(9 Pt B):1870-85. doi: 10.1016/j.jmb.2015.11.016. Epub 2015 Dec 1. J Mol Biol. 2016. PMID: 26608812 Free PMC article. Review.

8

Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures.

Weaver CL, Duran EC, Mack KL, Lin J, Jackrel ME, Sweeny EA, Shorter J, Lucius AL. Weaver CL, et al. Among authors: sweeny ea. Biochemistry. 2017 Apr 18;56(15):2071-2075. doi: 10.1021/acs.biochem.7b00225. Epub 2017 Apr 10. Biochemistry. 2017. PMID: 28379007 Free PMC article.

9

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Gates SN, et al. Among authors: sweeny ea. Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15. Science. 2017. PMID: 28619716 Free PMC article.

10

Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting.

Sweeny EA, Tariq A, Gurpinar E, Go MS, Sochor MA, Kan ZY, Mayne L, Englander SW, Shorter J. Sweeny EA, et al. J Biol Chem. 2020 Feb 7;295(6):1517-1538. doi: 10.1074/jbc.RA119.011577. Epub 2019 Dec 27. J Biol Chem. 2020. PMID: 31882541 Free PMC article.

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