Gopalsamy A - Search Results

1

A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.

Bodine PV, Stauffer B, Ponce-de-Leon H, Bhat RA, Mangine A, Seestaller-Wehr LM, Moran RA, Billiard J, Fukayama S, Komm BS, Pitts K, Krishnamurthy G, Gopalsamy A, Shi M, Kern JC, Commons TJ, Woodworth RP, Wilson MA, Welmaker GS, Trybulski EJ, Moore WJ. Bodine PV, et al. Among authors: gopalsamy a. Bone. 2009 Jun;44(6):1063-8. doi: 10.1016/j.bone.2009.02.013. Epub 2009 Feb 27. Bone. 2009. PMID: 19254787

2

Identification of diarylsulfone sulfonamides as secreted frizzled related protein-1 (sFRP-1) inhibitors.

Gopalsamy A, Shi M, Stauffer B, Bahat R, Billiard J, Ponce-de-Leon H, Seestaller-Wehr L, Fukayama S, Mangine A, Moran R, Krishnamurthy G, Bodine P. Gopalsamy A, et al. J Med Chem. 2008 Dec 25;51(24):7670-2. doi: 10.1021/jm801069w. J Med Chem. 2008. PMID: 19053830

3

Identification of iminooxothiazolidines as secreted frizzled related protein-1 inhibitors.

Shi M, Stauffer B, Bhat R, Billiard J, Ponce-de-Leon H, Seestaller-Wehr L, Fukayama S, Mangine A, Moran R, Krishnamurthy G, Bodine P, Gopalsamy A. Shi M, et al. Among authors: gopalsamy a. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6337-9. doi: 10.1016/j.bmcl.2009.09.085. Epub 2009 Sep 25. Bioorg Med Chem Lett. 2009. PMID: 19819694

4

Novel synthetic approach to 6,7-dihydro-5H-imidazo[1,5-a]-pyrazin-8-ones.

Gopalsamy A, Shi M. Gopalsamy A, et al. Org Lett. 2003 Oct 16;5(21):3907-9. doi: 10.1021/ol035455i. Org Lett. 2003. PMID: 14535740

5

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.

Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS. Gopalsamy A, et al. J Med Chem. 2006 Jun 1;49(11):3052-5. doi: 10.1021/jm060168g. J Med Chem. 2006. PMID: 16722622

6

Discovery of dibenzo[c,f][2,7]naphthyridines as potent and selective 3-phosphoinositide-dependent kinase-1 inhibitors.

Gopalsamy A, Shi M, Boschelli DH, Williamson R, Olland A, Hu Y, Krishnamurthy G, Han X, Arndt K, Guo B. Gopalsamy A, et al. J Med Chem. 2007 Nov 15;50(23):5547-9. doi: 10.1021/jm070851i. Epub 2007 Oct 17. J Med Chem. 2007. PMID: 17941624

7

Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

Gopalsamy A, Lim K, Ellingboe JW, Krishnamurthy G, Orlowski M, Feld B, van Zeijl M, Howe AY. Gopalsamy A, et al. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4221-4. doi: 10.1016/j.bmcl.2004.06.013. Bioorg Med Chem Lett. 2004. PMID: 15261274

8

Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1.

Gopalsamy A, Kincaid SL, Ellingboe JW, Groeling TM, Antrilli TM, Krishnamurthy G, Aulabaugh A, Friedrichs GS, Crandall DL. Gopalsamy A, et al. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3477-80. doi: 10.1016/j.bmcl.2004.04.058. Bioorg Med Chem Lett. 2004. PMID: 15177456

9

B-Raf kinase inhibitors: hit enrichment through scaffold hopping.

Gopalsamy A, Shi M, Hu Y, Lee F, Feldberg L, Frommer E, Kim S, Collins K, Wojciechowicz D, Mallon R. Gopalsamy A, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2431-4. doi: 10.1016/j.bmcl.2010.03.030. Epub 2010 Mar 9. Bioorg Med Chem Lett. 2010. PMID: 20307980

10

Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors.

Gopalsamy A, Ciszewski G, Shi M, Berger D, Hu Y, Lee F, Feldberg L, Frommer E, Kim S, Collins K, Wojciechowicz D, Mallon R. Gopalsamy A, et al. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. doi: 10.1016/j.bmcl.2009.10.074. Epub 2009 Oct 22. Bioorg Med Chem Lett. 2009. PMID: 19884006

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