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Adenosine signaling, priapism and novel therapies.
Dai Y, Zhang Y, Phatarpekar P, Mi T, Zhang H, Blackburn MR, Xia Y. Dai Y, et al. J Sex Med. 2009 Mar;6 Suppl 3:292-301. doi: 10.1111/j.1743-6109.2008.01187.x. J Sex Med. 2009. PMID: 19267852 Review.
Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling.
Wen J, Jiang X, Dai Y, Zhang Y, Tang Y, Sun H, Mi T, Phatarpekar PV, Kellems RE, Blackburn MR, Xia Y. Wen J, et al. Among authors: dai y. FASEB J. 2010 Mar;24(3):740-9. doi: 10.1096/fj.09-144147. Epub 2009 Oct 26. FASEB J. 2010. PMID: 19858092 Free PMC article.
Overall, our studies identify an essential role of increased adenosine in the pathogenesis of penile fibrosis via A(2B)R signaling and offer a potential target for prevention and treatment of penile fibrosis, a dangerous complication seen in priapism.-Wen, J., Jiang, X., Dai …
Overall, our studies identify an essential role of increased adenosine in the pathogenesis of penile fibrosis via A(2B)R signaling and offer …
Detrimental effects of adenosine signaling in sickle cell disease.
Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, Carter-Dawson L, Lewis DE, Zhang W, Eltzschig HK, Kellems RE, Blackburn MR, Juneja HS, Xia Y. Zhang Y, et al. Among authors: dai y. Nat Med. 2011 Jan;17(1):79-86. doi: 10.1038/nm.2280. Epub 2010 Dec 19. Nat Med. 2011. PMID: 21170046 Free PMC article.
Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension.
Zhang W, Zhang Y, Wang W, Dai Y, Ning C, Luo R, Sun K, Glover L, Grenz A, Sun H, Tao L, Zhang W, Colgan SP, Blackburn MR, Eltzschig HK, Kellems RE, Xia Y. Zhang W, et al. Among authors: dai y. Circ Res. 2013 May 24;112(11):1466-78. doi: 10.1161/CIRCRESAHA.111.300166. Epub 2013 Apr 12. Circ Res. 2013. PMID: 23584256 Free PMC article.
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