Tang WJ - Search Results

1

Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme.

Manolopoulou M, Guo Q, Malito E, Schilling AB, Tang WJ. Manolopoulou M, et al. Among authors: tang wj. J Biol Chem. 2009 May 22;284(21):14177-88. doi: 10.1074/jbc.M900068200. Epub 2009 Mar 25. J Biol Chem. 2009. PMID: 19321446 Free PMC article.

2

The conserved asparagine and arginine are essential for catalysis of mammalian adenylyl cyclase.

Yan SZ, Huang ZH, Shaw RS, Tang WJ. Yan SZ, et al. Among authors: tang wj. J Biol Chem. 1997 May 9;272(19):12342-9. doi: 10.1074/jbc.272.19.12342. J Biol Chem. 1997. PMID: 9139678 Free article.

3

Three discrete regions of mammalian adenylyl cyclase form a site for Gsalpha activation.

Yan SZ, Huang ZH, Rao VD, Hurley JH, Tang WJ. Yan SZ, et al. Among authors: tang wj. J Biol Chem. 1997 Jul 25;272(30):18849-54. doi: 10.1074/jbc.272.30.18849. J Biol Chem. 1997. PMID: 9228061 Free article.

4

An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis.

Drum CL, Yan SZ, Sarac R, Mabuchi Y, Beckingham K, Bohm A, Grabarek Z, Tang WJ. Drum CL, et al. Among authors: tang wj. J Biol Chem. 2000 Nov 17;275(46):36334-40. doi: 10.1074/jbc.M004778200. J Biol Chem. 2000. PMID: 10926933 Free article.

5

The regulation of type 7 adenylyl cyclase by its C1b region and Escherichia coli peptidylprolyl isomerase, SlyD.

Yan SZ, Beeler JA, Chen Y, Shelton RK, Tang WJ. Yan SZ, et al. Among authors: tang wj. J Biol Chem. 2001 Mar 16;276(11):8500-6. doi: 10.1074/jbc.M010361200. Epub 2000 Dec 11. J Biol Chem. 2001. PMID: 11113152 Free article.

6

Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.

Soelaiman S, Wei BQ, Bergson P, Lee YS, Shen Y, Mrksich M, Shoichet BK, Tang WJ. Soelaiman S, et al. Among authors: tang wj. J Biol Chem. 2003 Jul 11;278(28):25990-7. doi: 10.1074/jbc.M301232200. Epub 2003 Apr 3. J Biol Chem. 2003. PMID: 12676933 Free article.

7

Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction.

Simons PC, Biggs SM, Waller A, Foutz T, Cimino DF, Guo Q, Neubig RR, Tang WJ, Prossnitz ER, Sklar LA. Simons PC, et al. Among authors: tang wj. J Biol Chem. 2004 Apr 2;279(14):13514-21. doi: 10.1074/jbc.M310306200. Epub 2004 Jan 15. J Biol Chem. 2004. PMID: 14726530 Free article.

8

Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site.

Shen Y, Guo Q, Zhukovskaya NL, Drum CL, Bohm A, Tang WJ. Shen Y, et al. Among authors: tang wj. Biochem Biophys Res Commun. 2004 Apr 30;317(2):309-14. doi: 10.1016/j.bbrc.2004.03.046. Biochem Biophys Res Commun. 2004. PMID: 15063758

9

Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.

Guo Q, Shen Y, Zhukovskaya NL, Florián J, Tang WJ. Guo Q, et al. Among authors: tang wj. J Biol Chem. 2004 Jul 9;279(28):29427-35. doi: 10.1074/jbc.M402689200. Epub 2004 May 6. J Biol Chem. 2004. PMID: 15131111 Free article.

10

Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.

Shen Y, Zhukovskaya NL, Guo Q, Florián J, Tang WJ. Shen Y, et al. Among authors: tang wj. EMBO J. 2005 Mar 9;24(5):929-41. doi: 10.1038/sj.emboj.7600574. Epub 2005 Feb 17. EMBO J. 2005. PMID: 15719022 Free PMC article.

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