Venkatakrishnan K - Search Results

1

Biotransformation of an alpha4beta2 nicotinic acetylcholine receptor partial agonist in sprague-dawley rats and the dispositional characterization of its N-carbamoyl glucuronide metabolite.

Shaffer CL, Ryder TF, Venkatakrishnan K, Henne IK, O'Connell TN. Shaffer CL, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2009 Jul;37(7):1480-9. doi: 10.1124/dmd.109.027037. Epub 2009 Apr 1. Drug Metab Dispos. 2009. PMID: 19339375

2

Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway.

Kalgutkar AS, Taylor TJ, Venkatakrishnan K, Isin EM. Kalgutkar AS, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2003 Mar;31(3):243-9. doi: 10.1124/dmd.31.3.243. Drug Metab Dispos. 2003. PMID: 12584149

3

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model.

Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, Cianfrogna J, Cox LM, Gibbs JP, Gibbs MA, Hatch H, Hop CE, Kasman IN, Laperle J, Liu J, Liu X, Logman M, Maclin D, Nedza FM, Nelson F, Olson E, Rahematpura S, Raunig D, Rogers S, Schmidt K, Spracklin DK, Szewc M, Troutman M, Tseng E, Tu M, Van Deusen JW, Venkatakrishnan K, Walens G, Wang EQ, Wong D, Yasgar AS, Zhang C. Doran A, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2005 Jan;33(1):165-74. doi: 10.1124/dmd.104.001230. Epub 2004 Oct 22. Drug Metab Dispos. 2005. PMID: 15502009

4

In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: prediction of nonstationary pharmacokinetics and drug interaction magnitude.

Venkatakrishnan K, Obach RS. Venkatakrishnan K, et al. Drug Metab Dispos. 2005 Jun;33(6):845-52. doi: 10.1124/dmd.105.004077. Epub 2005 Mar 23. Drug Metab Dispos. 2005. PMID: 15788540

5

Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions.

Obach RS, Walsky RL, Venkatakrishnan K. Obach RS, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2007 Feb;35(2):246-55. doi: 10.1124/dmd.106.012633. Epub 2006 Nov 8. Drug Metab Dispos. 2007. PMID: 17093004

6

Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures.

Venkatakrishnan K, Tseng E, Nelson FR, Rollema H, French JL, Kaplan IV, Horner WE, Gibbs MA. Venkatakrishnan K, et al. Drug Metab Dispos. 2007 Aug;35(8):1341-9. doi: 10.1124/dmd.106.013953. Epub 2007 Apr 30. Drug Metab Dispos. 2007. PMID: 17470526

7

Metabolism and disposition of a gamma-aminobutyric acid type A receptor partial agonist in humans.

Shaffer CL, Gunduz M, Vaz AD, Venkatakrishnan K, Burstein AH. Shaffer CL, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2008 Apr;36(4):655-62. doi: 10.1124/dmd.107.019760. Epub 2008 Jan 7. Drug Metab Dispos. 2008. PMID: 18180269

8

Biotransformation Pathways and Metabolite Profiles of Oral [¹⁴C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.

Pusalkar S, Zhou X, Li Y, Cohen L, Yang JJ, Balani SK, Xia C, Shyu WC, Lu C, Venkatakrishnan K, Chowdhury SK. Pusalkar S, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2020 Mar;48(3):217-229. doi: 10.1124/dmd.119.087338. Epub 2020 Jan 7. Drug Metab Dispos. 2020. PMID: 31911485 Free PMC article.

9

Drug metabolism and drug interactions: application and clinical value of in vitro models.

Venkatakrishnan K, von Moltke LL, Obach RS, Greenblatt DJ. Venkatakrishnan K, et al. Curr Drug Metab. 2003 Oct;4(5):423-59. doi: 10.2174/1389200033489361. Curr Drug Metab. 2003. PMID: 14529374 Review.

10

Absolute oral bioavailability of traxoprodil in cytochrome P450 2D6 extensive and poor metabolisers.

Taylor TJ, Diringer K, Russell T, Venkatakrishnan K, Wilner K, Crownover PH, Benincosa LJ, Gibbs MA. Taylor TJ, et al. Among authors: venkatakrishnan k. Clin Pharmacokinet. 2006;45(10):989-1001. doi: 10.2165/00003088-200645100-00003. Clin Pharmacokinet. 2006. PMID: 16984212 Clinical Trial.

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