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VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis.
Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong GH, Ding H, Greenberg DA, Becker KG, Herbert JM, Nash A, Yla-Herttuala S, Cao Y, Watts RJ, Li X. Zhang F, et al. Among authors: li y, li x. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6152-7. doi: 10.1073/pnas.0813061106. Epub 2009 Apr 6. Proc Natl Acad Sci U S A. 2009. PMID: 19369214 Free PMC article.
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.
Li X, Tjwa M, Moons L, Fons P, Noel A, Ny A, Zhou JM, Lennartsson J, Li H, Luttun A, Pontén A, Devy L, Bouché A, Oh H, Manderveld A, Blacher S, Communi D, Savi P, Bono F, Dewerchin M, Foidart JM, Autiero M, Herbert JM, Collen D, Heldin CH, Eriksson U, Carmeliet P. Li X, et al. Among authors: li h. J Clin Invest. 2005 Jan;115(1):118-27. doi: 10.1172/JCI19189. J Clin Invest. 2005. PMID: 15630451 Free PMC article.
VEGF-B: a survival, or an angiogenic factor?
Li X, Lee C, Tang Z, Zhang F, Arjunan P, Li Y, Hou X, Kumar A, Dong L. Li X, et al. Among authors: li y. Cell Adh Migr. 2009 Oct-Dec;3(4):322-7. doi: 10.4161/cam.3.4.9459. Epub 2009 Oct 3. Cell Adh Migr. 2009. PMID: 19684473 Free PMC article. Review.
Platelet-derived growth factor-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase-3beta phosphorylation.
Kumar A, Hou X, Lee C, Li Y, Maminishkis A, Tang Z, Zhang F, Langer HF, Arjunan P, Dong L, Wu Z, Zhu LY, Wang L, Min W, Colosi P, Chavakis T, Li X. Kumar A, et al. Among authors: li y, li x. J Biol Chem. 2010 May 14;285(20):15500-15510. doi: 10.1074/jbc.M110.113787. Epub 2010 Mar 15. J Biol Chem. 2010. PMID: 20231273 Free PMC article.
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation.
Tang Z, Arjunan P, Lee C, Li Y, Kumar A, Hou X, Wang B, Wardega P, Zhang F, Dong L, Zhang Y, Zhang SZ, Ding H, Fariss RN, Becker KG, Lennartsson J, Nagai N, Cao Y, Li X. Tang Z, et al. Among authors: li y, li x. J Exp Med. 2010 Apr 12;207(4):867-80. doi: 10.1084/jem.20091704. Epub 2010 Mar 15. J Exp Med. 2010. PMID: 20231377 Free PMC article.
PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.
Hou X, Kumar A, Lee C, Wang B, Arjunan P, Dong L, Maminishkis A, Tang Z, Li Y, Zhang F, Zhang SZ, Wardega P, Chakrabarty S, Liu B, Wu Z, Colosi P, Fariss RN, Lennartsson J, Nussenblatt R, Gutkind JS, Cao Y, Li X. Hou X, et al. Among authors: li y, li x. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12216-21. doi: 10.1073/pnas.1004143107. Epub 2010 Jun 21. Proc Natl Acad Sci U S A. 2010. PMID: 20566880 Free PMC article.
Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis.
Langer HF, Chung KJ, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, DeAngelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD, Chavakis T. Langer HF, et al. Among authors: li x. Blood. 2010 Nov 25;116(22):4395-403. doi: 10.1182/blood-2010-01-261503. Epub 2010 Jul 12. Blood. 2010. PMID: 20625009 Free PMC article.
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