Bogen SL - Search Results

1

Toward second generation hepatitis C virus NS3 serine protease inhibitors: discovery of novel P4 modified analogues with improved potency and pharmacokinetic profile.

Arasappan A, Padilla AI, Jao E, Bennett F, Bogen SL, Chen KX, Pike RE, Sannigrahi M, Soares J, Venkatraman S, Vibulbhan B, Saksena AK, Girijavallabhan V, Tong X, Cheng KC, Njoroge FG. Arasappan A, et al. Among authors: bogen sl. J Med Chem. 2009 May 14;52(9):2806-17. doi: 10.1021/jm801616e. J Med Chem. 2009. PMID: 19371095

2

In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease.

Liu R, Abid K, Pichardo J, Pazienza V, Ingravallo P, Kong R, Agrawal S, Bogen S, Saksena A, Cheng KC, Prongay A, Njoroge FG, Baroudy BM, Negro F. Liu R, et al. J Antimicrob Chemother. 2007 Jan;59(1):51-8. doi: 10.1093/jac/dkl455. Epub 2006 Dec 5. J Antimicrob Chemother. 2007. PMID: 17151003

3

Characterization of resistance mutations against HCV ketoamide protease inhibitors.

Tong X, Bogen S, Chase R, Girijavallabhan V, Guo Z, Njoroge FG, Prongay A, Saksena A, Skelton A, Xia E, Ralston R. Tong X, et al. Antiviral Res. 2008 Mar;77(3):177-85. doi: 10.1016/j.antiviral.2007.11.010. Epub 2007 Dec 28. Antiviral Res. 2008. PMID: 18201776

4

Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.

Venkatraman S, Velazquez F, Wu W, Blackman M, Chen KX, Bogen S, Nair L, Tong X, Chase R, Hart A, Agrawal S, Pichardo J, Prongay A, Cheng KC, Girijavallabhan V, Piwinski J, Shih NY, Njoroge FG. Venkatraman S, et al. J Med Chem. 2009 Jan 22;52(2):336-46. doi: 10.1021/jm800940u. J Med Chem. 2009. PMID: 19102654

5

Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.

Velázquez F, Venkatraman S, Blackman M, Pinto P, Bogen S, Sannigrahi M, Chen K, Pichardo J, Hart A, Tong X, Girijavallabhan V, Njoroge FG. Velázquez F, et al. J Med Chem. 2009 Feb 12;52(3):700-8. doi: 10.1021/jm801201u. J Med Chem. 2009. PMID: 19154150

6

Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.

Venkatraman S, Blackman M, Wu W, Nair L, Arasappan A, Padilla A, Bogen S, Bennett F, Chen K, Pichardo J, Tong X, Prongay A, Cheng KC, Girijavallabhan V, George Njoroge F. Venkatraman S, et al. Bioorg Med Chem. 2009 Jul 1;17(13):4486-95. doi: 10.1016/j.bmc.2009.05.012. Epub 2009 May 9. Bioorg Med Chem. 2009. PMID: 19481946

7

P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile.

Nair LG, Sannigrahi M, Bogen S, Pinto P, Chen KX, Prongay A, Tong X, Cheng KC, Girijavallabhan V, George Njoroge F. Nair LG, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):567-70. doi: 10.1016/j.bmcl.2009.11.094. Epub 2009 Nov 22. Bioorg Med Chem Lett. 2010. PMID: 20004570

8

Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors.

Nair LG, Bogen S, Ruan S, Pan W, Pike R, Tong X, Cheng KC, Guo Z, Doll RJ, Njoroge FG. Nair LG, et al. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1689-92. doi: 10.1016/j.bmcl.2010.01.037. Epub 2010 Jan 20. Bioorg Med Chem Lett. 2010. PMID: 20149655

9

Cyclic sulfones as novel P3-caps for hepatitis C virus NS3/4A (HCV NS3/4A) protease inhibitors: synthesis and evaluation of inhibitors with improved potency and pharmacokinetic profiles.

Velázquez F, Sannigrahi M, Bennett F, Lovey RG, Arasappan A, Bogen S, Nair L, Venkatraman S, Blackman M, Hendrata S, Huang Y, Huelgas R, Pinto P, Cheng KC, Tong X, McPhail AT, Njoroge FG. Velázquez F, et al. J Med Chem. 2010 Apr 22;53(8):3075-85. doi: 10.1021/jm9016027. J Med Chem. 2010. PMID: 20302300

10

Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.

Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG. Bogen SL, et al. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. doi: 10.1016/j.bmcl.2005.12.013. Epub 2006 Jan 4. Bioorg Med Chem Lett. 2006. PMID: 16387495

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