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Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner.
Borissoff JI, Otten JJ, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele ST, Hamulyák K, Hackeng TM, Daemen MJ, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EA, Spronk HM, ten Cate H. Borissoff JI, et al. Among authors: leenders p. PLoS One. 2013;8(2):e55784. doi: 10.1371/journal.pone.0055784. Epub 2013 Feb 7. PLoS One. 2013. PMID: 23409043 Free PMC article.
Monitoring platelet dependent thrombin generation in mice.
Dargaud Y, Spronk HM, Leenders P, Hemker HC, Ten Cate H. Dargaud Y, et al. Among authors: leenders p. Thromb Res. 2010 Nov;126(5):436-41. doi: 10.1016/j.thromres.2010.08.007. Epub 2010 Sep 16. Thromb Res. 2010. PMID: 20843543
Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery.
Mastenbroek TG, Karel MFA, Nagy M, Chayoua W, Korsten EIJ, Coenen DM, Debets J, Konings J, Brouns AE, Leenders PJA, van Essen H, van Oerle R, Heitmeier S, Spronk HM, Kuijpers MJE, Cosemans JMEM. Mastenbroek TG, et al. Among authors: leenders pja. Sci Rep. 2020 Nov 9;10(1):19360. doi: 10.1038/s41598-020-76377-8. Sci Rep. 2020. PMID: 33168914 Free PMC article.
Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate.
van Gorp RH, Dijkgraaf I, Bröker V, Bauwens M, Leenders P, Jennen D, Dweck MR, Bucerius J, Briedé JJ, van Ryn J, Brandenburg V, Mottaghy F, Spronk HMH, Reutelingsperger CP, Schurgers LJ. van Gorp RH, et al. Among authors: leenders p. J Thromb Haemost. 2021 May;19(5):1348-1363. doi: 10.1111/jth.15289. Epub 2021 Mar 28. J Thromb Haemost. 2021. PMID: 33687782 Free PMC article.
Vitamin K antagonist use induces calcification and atherosclerotic plaque progression resulting in increased hypercoagulability.
van Gorp RH, Baaten CCFMJ, Habibi A, Jaminon AMG, Peeters FECM, Leenders P, Crijns HJGMC, Heemskerk JWM, Reutelingsperger CP, Spronk HM, Schurgers LJ. van Gorp RH, et al. Among authors: leenders p. Eur Heart J Open. 2021 Aug 6;1(2):oeab017. doi: 10.1093/ehjopen/oeab017. eCollection 2021 Sep. Eur Heart J Open. 2021. PMID: 35919270 Free PMC article.
28 results