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Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.
Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium; Spieler D, Klingenspor M, Seifert M, Kern MJ, Mejhert N, Dahlman I, Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K, Hsu YH, Mellgren G, Hauner H, Laumen H. Claussnitzer M, et al. Among authors: hoffmann c. Cell. 2014 Jan 16;156(1-2):343-58. doi: 10.1016/j.cell.2013.10.058. Cell. 2014. PMID: 24439387 Free PMC article.
Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation.
Lee H, Qian K, von Toerne C, Hoerburger L, Claussnitzer M, Hoffmann C, Glunk V, Wahl S, Breier M, Eck F, Jafari L, Molnos S, Grallert H, Dahlman I, Arner P, Brunner C, Hauner H, Hauck SM, Laumen H. Lee H, et al. Among authors: hoffmann c. Nucleic Acids Res. 2017 Apr 7;45(6):3266-3279. doi: 10.1093/nar/gkx105. Nucleic Acids Res. 2017. PMID: 28334807 Free PMC article.
TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle.
Böhm A, Hoffmann C, Irmler M, Schneeweiss P, Schnauder G, Sailer C, Schmid V, Hudemann J, Machann J, Schick F, Beckers J, Hrabě de Angelis M, Staiger H, Fritsche A, Stefan N, Nieß AM, Häring HU, Weigert C. Böhm A, et al. Among authors: hoffmann c. Diabetes. 2016 Oct;65(10):2849-61. doi: 10.2337/db15-1723. Epub 2016 Jun 29. Diabetes. 2016. PMID: 27358493 Clinical Trial.
Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints.
Kappler L, Hoene M, Hu C, von Toerne C, Li J, Bleher D, Hoffmann C, Böhm A, Kollipara L, Zischka H, Königsrainer A, Häring HU, Peter A, Xu G, Sickmann A, Hauck SM, Weigert C, Lehmann R. Kappler L, et al. Among authors: hoffmann c. Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E374-E387. doi: 10.1152/ajpendo.00088.2019. Epub 2019 Jun 18. Am J Physiol Endocrinol Metab. 2019. PMID: 31211616 Free article.
Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability.
Hoene M, Kappler L, Kollipara L, Hu C, Irmler M, Bleher D, Hoffmann C, Beckers J, Hrabě de Angelis M, Häring HU, Birkenfeld AL, Peter A, Sickmann A, Xu G, Lehmann R, Weigert C. Hoene M, et al. Among authors: hoffmann c. Mol Metab. 2021 Dec;54:101359. doi: 10.1016/j.molmet.2021.101359. Epub 2021 Oct 22. Mol Metab. 2021. PMID: 34695608 Free PMC article.
TGF-β Induction of miR-143/145 Is Associated to Exercise Response by Influencing Differentiation and Insulin Signaling Molecules in Human Skeletal Muscle.
Dreher SI, Höckele S, Huypens P, Irmler M, Hoffmann C, Jeske T, Hastreiter M, Moller A, Birkenfeld AL, Häring HU, Peter A, Beckers J, Hrabě de Angelis M, Weigert C. Dreher SI, et al. Among authors: hoffmann c. Cells. 2021 Dec 7;10(12):3443. doi: 10.3390/cells10123443. Cells. 2021. PMID: 34943951 Free PMC article.
1,631 results