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The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes.
Paxman JJ, Borg NA, Horne J, Thompson PE, Chin Y, Sharma P, Simpson JS, Wielens J, Piek S, Kahler CM, Sakellaris H, Pearce M, Bottomley SP, Rossjohn J, Scanlon MJ. Paxman JJ, et al. Among authors: bottomley sp. J Biol Chem. 2009 Jun 26;284(26):17835-45. doi: 10.1074/jbc.M109.011502. Epub 2009 Apr 22. J Biol Chem. 2009. PMID: 19389711 Free PMC article.
Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis.
Vivian JP, Scoullar J, Robertson AL, Bottomley SP, Horne J, Chin Y, Wielens J, Thompson PE, Velkov T, Piek S, Byres E, Beddoe T, Wilce MC, Kahler CM, Rossjohn J, Scanlon MJ. Vivian JP, et al. Among authors: bottomley sp. J Biol Chem. 2008 Nov 21;283(47):32452-61. doi: 10.1074/jbc.M803990200. Epub 2008 Aug 20. J Biol Chem. 2008. PMID: 18715864 Free article.
A biophysical analysis of the tetratricopeptide repeat-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable, and unfolds via a multistate pathway.
Beddoe T, Bushell SR, Perugini MA, Lithgow T, Mulhern TD, Bottomley SP, Rossjohn J. Beddoe T, et al. Among authors: bottomley sp. J Biol Chem. 2004 Nov 5;279(45):46448-54. doi: 10.1074/jbc.M405639200. Epub 2004 Aug 16. J Biol Chem. 2004. PMID: 15316022 Free article.
The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.
Law RH, Irving JA, Buckle AM, Ruzyla K, Buzza M, Bashtannyk-Puhalovich TA, Beddoe TC, Nguyen K, Worrall DM, Bottomley SP, Bird PI, Rossjohn J, Whisstock JC. Law RH, et al. Among authors: bottomley sp. J Biol Chem. 2005 Jun 10;280(23):22356-64. doi: 10.1074/jbc.M412043200. Epub 2005 Mar 10. J Biol Chem. 2005. PMID: 15760906 Free article.
The structure of H-2K(b) and K(bm8) complexed to a herpes simplex virus determinant: evidence for a conformational switch that governs T cell repertoire selection and viral resistance.
Webb AI, Borg NA, Dunstone MA, Kjer-Nielsen L, Beddoe T, McCluskey J, Carbone FR, Bottomley SP, Aguilar MI, Purcell AW, Rossjohn J. Webb AI, et al. Among authors: bottomley sp. J Immunol. 2004 Jul 1;173(1):402-9. doi: 10.4049/jimmunol.173.1.402. J Immunol. 2004. PMID: 15210799
160 results