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First-in-Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers.
Fox JC, Hellawell JL, Rao S, O'Reilly T, Lumpkin R, Jernelius J, Gretler D, Sinha U. Fox JC, et al. Among authors: hellawell jl. Clin Pharmacol Drug Dev. 2020 Jan;9(1):115-129. doi: 10.1002/cpdd.700. Epub 2019 Jun 6. Clin Pharmacol Drug Dev. 2020. PMID: 31172685 Free PMC article. Clinical Trial.
Novel Approach Targeting the Complex Pathophysiology of Hypertrophic Cardiomyopathy: The Impact of Late Sodium Current Inhibition on Exercise Capacity in Subjects with Symptomatic Hypertrophic Cardiomyopathy (LIBERTY-HCM) Trial.
Olivotto I, Hellawell JL, Farzaneh-Far R, Blair C, Coppini R, Myers J, Belardinelli L, Maron MS. Olivotto I, et al. Among authors: hellawell jl. Circ Heart Fail. 2016 Mar;9(3):e002764. doi: 10.1161/CIRCHEARTFAILURE.115.002764. Circ Heart Fail. 2016. PMID: 26915375 Clinical Trial.
Myocardial reverse remodeling.
Hellawell JL, Margulies KB. Hellawell JL, et al. Cardiovasc Ther. 2012 Jun;30(3):172-81. doi: 10.1111/j.1755-5922.2010.00247.x. Epub 2010 Nov 25. Cardiovasc Ther. 2012. PMID: 21108773 Free article. Review.