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Extracellular sodium interacts with the HERG channel at an outer pore site.
Mullins FM, Stepanovic SZ, Desai RR, George AL Jr, Balser JR. Mullins FM, et al. Among authors: balser jr. J Gen Physiol. 2002 Oct;120(4):517-37. doi: 10.1085/jgp.20028589. J Gen Physiol. 2002. PMID: 12356854 Free PMC article.
Most voltage-gated K(+) currents are relatively insensitive to extracellular Na(+) (Na(+)(o)), but Na(+)(o) potently inhibits outward human ether-a-go-go-related gene (HERG)-encoded K(+) channel current (Numaguchi, H., J.P. Johnson, Jr., C.I. Petersen, and J.R. Balser …
Most voltage-gated K(+) currents are relatively insensitive to extracellular Na(+) (Na(+)(o)), but Na(+)(o) potently inhibits outward human …
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias.
Potet F, Lorinc AN, Chaigne S, Hopkins CR, Venkataraman R, Stepanovic SZ, Lewis LM, Days E, Sidorov VY, Engers DW, Zou B, Afshartous D, George AL Jr, Campbell CM, Balser JR, Li M, Baudenbacher FJ, Lindsley CW, Weaver CD, Kupershmidt S. Potet F, et al. Among authors: balser jr. J Biol Chem. 2012 Nov 16;287(47):39613-25. doi: 10.1074/jbc.M112.380162. Epub 2012 Oct 2. J Biol Chem. 2012. PMID: 23033485 Free PMC article.
In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.
Petersen CI, McFarland TR, Stepanovic SZ, Yang P, Reiner DJ, Hayashi K, George AL, Roden DM, Thomas JH, Balser JR. Petersen CI, et al. Among authors: balser jr. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11773-8. doi: 10.1073/pnas.0306005101. Epub 2004 Jul 27. Proc Natl Acad Sci U S A. 2004. PMID: 15280551 Free PMC article.
84 results