Marciniak SJ - Search Results

1

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies.

Ekeowa UI, Gooptu B, Belorgey D, Hägglöf P, Karlsson-Li S, Miranda E, Pérez J, MacLeod I, Kroger H, Marciniak SJ, Crowther DC, Lomas DA. Ekeowa UI, et al. Among authors: marciniak sj. Clin Sci (Lond). 2009 May 14;116(12):837-50. doi: 10.1042/CS20080484. Clin Sci (Lond). 2009. PMID: 19426146 Review.

2

Intracellular serpins, firewalls and tissue necrosis.

Marciniak SJ, Lomas DA. Marciniak SJ, et al. Trends Cell Biol. 2008 Feb;18(2):45-7. doi: 10.1016/j.tcb.2007.11.006. Epub 2008 Jan 22. Trends Cell Biol. 2008. PMID: 18215520

3

What can naturally occurring mutations tell us about the pathogenesis of COPD?

Marciniak SJ, Lomas DA. Marciniak SJ, et al. Thorax. 2009 Apr;64(4):359-64. doi: 10.1136/thx.2008.099408. Thorax. 2009. PMID: 19329735 Review.

4

Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response.

Davies MJ, Miranda E, Roussel BD, Kaufman RJ, Marciniak SJ, Lomas DA. Davies MJ, et al. Among authors: marciniak sj. J Biol Chem. 2009 Jul 3;284(27):18202-9. doi: 10.1074/jbc.M109.010744. Epub 2009 May 7. J Biol Chem. 2009. PMID: 19423713 Free PMC article.

5

Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins.

Kroeger H, Miranda E, MacLeod I, Pérez J, Crowther DC, Marciniak SJ, Lomas DA. Kroeger H, et al. Among authors: marciniak sj. J Biol Chem. 2009 Aug 21;284(34):22793-802. doi: 10.1074/jbc.M109.027102. Epub 2009 Jun 23. J Biol Chem. 2009. PMID: 19549782 Free PMC article.

6

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.

Miranda E, Pérez J, Ekeowa UI, Hadzic N, Kalsheker N, Gooptu B, Portmann B, Belorgey D, Hill M, Chambers S, Teckman J, Alexander GJ, Marciniak SJ, Lomas DA. Miranda E, et al. Among authors: marciniak sj. Hepatology. 2010 Sep;52(3):1078-88. doi: 10.1002/hep.23760. Hepatology. 2010. PMID: 20583215

7

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response.

Malzer E, Daly ML, Moloney A, Sendall TJ, Thomas SE, Ryder E, Ryoo HD, Crowther DC, Lomas DA, Marciniak SJ. Malzer E, et al. Among authors: marciniak sj. J Cell Sci. 2010 Sep 1;123(Pt 17):2892-900. doi: 10.1242/jcs.070078. Epub 2010 Aug 3. J Cell Sci. 2010. PMID: 20682638 Free PMC article.

8

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.

Rashid ST, Corbineau S, Hannan N, Marciniak SJ, Miranda E, Alexander G, Huang-Doran I, Griffin J, Ahrlund-Richter L, Skepper J, Semple R, Weber A, Lomas DA, Vallier L. Rashid ST, et al. Among authors: marciniak sj. J Clin Invest. 2010 Sep;120(9):3127-36. doi: 10.1172/JCI43122. Epub 2010 Aug 25. J Clin Invest. 2010. PMID: 20739751 Free PMC article.

9

Alpha1-antitrypsin deficiency and autophagy.

Marciniak SJ, Lomas DA. Marciniak SJ, et al. N Engl J Med. 2010 Nov 4;363(19):1863-4. doi: 10.1056/NEJMcibr1008007. N Engl J Med. 2010. PMID: 21047232 No abstract available.

10

Characterisation of serpin polymers in vitro and in vivo.

Belorgey D, Irving JA, Ekeowa UI, Freeke J, Roussel BD, Miranda E, Pérez J, Robinson CV, Marciniak SJ, Crowther DC, Michel CH, Lomas DA. Belorgey D, et al. Among authors: marciniak sj. Methods. 2011 Mar;53(3):255-66. doi: 10.1016/j.ymeth.2010.11.008. Epub 2010 Nov 27. Methods. 2011. PMID: 21115126 Review.

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