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309 results

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Page 1
IL1B polymorphisms modulate cystic fibrosis lung disease.
Levy H, Murphy A, Zou F, Gerard C, Klanderman B, Schuemann B, Lazarus R, García KC, Celedón JC, Drumm M, Dahmer M, Quasney M, Schneck K, Reske M, Knowles MR, Pier GB, Lange C, Weiss ST. Levy H, et al. Among authors: garcia kc. Pediatr Pulmonol. 2009 Jun;44(6):580-93. doi: 10.1002/ppul.21026. Pediatr Pulmonol. 2009. PMID: 19431193 Free PMC article.
Potent antitumor activity of a designed interleukin-21 mimic.
Chun JH, Lim BS, Roy S, Walsh MJ, Abhiraman GC, Zhangxu K, Atajanova T, Revach OY, Clark EC, Li P, Palin CA, Khanna A, Tower S, Kureshi R, Hoffman MT, Sharova T, Lawless A, Cohen S, Boland GM, Nguyen T, Peprah F, Tello JG, Liu SY, Kim CJ, Shin H, Quijano-Rubio A, Jude KM, Gerben S, Murray A, Heine P, DeWitt M, Ulge UY, Carter L, King NP, Silva DA, Kueh HY, Kalia V, Sarkar S, Jenkins RW, Garcia KC, Leonard WJ, Dougan M, Dougan SK, Baker D. Chun JH, et al. Among authors: garcia kc. bioRxiv [Preprint]. 2024 Dec 7:2024.12.06.626481. doi: 10.1101/2024.12.06.626481. bioRxiv. 2024. PMID: 39677740 Free PMC article. Preprint.
A general system for targeting MHC class II-antigen complex via a single adaptable loop.
Du H, Liu J, Jude KM, Yang X, Li Y, Bell B, Yang H, Kassardjian A, Blackson W, Mobedi A, Parekh U, Parra Sperberg RA, Julien JP, Mellins ED, Garcia KC, Huang PS. Du H, et al. Among authors: garcia kc. Nat Biotechnol. 2024 Dec 13. doi: 10.1038/s41587-024-02466-y. Online ahead of print. Nat Biotechnol. 2024. PMID: 39672953
Design of high specificity binders for peptide-MHC-I complexes.
Liu B, Greenwood NF, Bonzanini JE, Motmaen A, Sharp J, Wang C, Visani GM, Vafeados DK, Roullier N, Nourmohammad A, Garcia KC, Baker D. Liu B, et al. Among authors: garcia kc. bioRxiv [Preprint]. 2024 Nov 28:2024.11.28.625793. doi: 10.1101/2024.11.28.625793. bioRxiv. 2024. PMID: 39651227 Free PMC article. Preprint.
AlphaFold2 enables accurate deorphanization of ligands to single-pass receptors.
Banhos Danneskiold-Samsøe N, Kavi D, Jude KM, Nissen SB, Wat LW, Coassolo L, Zhao M, Santana-Oikawa GA, Broido BB, Garcia KC, Svensson KJ. Banhos Danneskiold-Samsøe N, et al. Among authors: garcia kc. Cell Syst. 2024 Nov 20;15(11):1046-1060.e3. doi: 10.1016/j.cels.2024.10.004. Epub 2024 Nov 13. Cell Syst. 2024. PMID: 39541981
Orientation-dependent CD45 inhibition with viral and engineered ligands.
Borowska MT, Liu LD, Caveney NA, Jude KM, Kim WJ, Masubuchi T, Hui E, Majzner RG, Garcia KC. Borowska MT, et al. Among authors: garcia kc. Sci Immunol. 2024 Oct 25;9(100):eadp0707. doi: 10.1126/sciimmunol.adp0707. Epub 2024 Oct 25. Sci Immunol. 2024. PMID: 39454026 Free PMC article.
De novo design of miniprotein antagonists of cytokine storm inducers.
Huang B, Coventry B, Borowska MT, Arhontoulis DC, Exposit M, Abedi M, Jude KM, Halabiya SF, Allen A, Cordray C, Goreshnik I, Ahlrichs M, Chan S, Tunggal H, DeWitt M, Hyams N, Carter L, Stewart L, Fuller DH, Mei Y, Garcia KC, Baker D. Huang B, et al. Among authors: garcia kc. Nat Commun. 2024 Aug 16;15(1):7064. doi: 10.1038/s41467-024-50919-4. Nat Commun. 2024. PMID: 39152100 Free PMC article.
309 results