Lozza G - Search Results

1

Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.

Sasikumar TK, Qiang L, Burnett DA, Greenlee WJ, Li C, Heimark L, Pramanik B, Grilli M, Bertorelli R, Lozza G, Reggiani A. Sasikumar TK, et al. Among authors: lozza g. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3199-203. doi: 10.1016/j.bmcl.2009.04.104. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19433355

2

Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain.

Wu WL, Burnett DA, Domalski M, Greenlee WJ, Li C, Bertorelli R, Fredduzzi S, Lozza G, Veltri A, Reggiani A. Wu WL, et al. Among authors: lozza g. J Med Chem. 2007 Nov 15;50(23):5550-3. doi: 10.1021/jm070590c. Epub 2007 Oct 11. J Med Chem. 2007. PMID: 17929793

3

A-ring modifications on the triazafluorenone core structure and their mGluR1 antagonist properties.

Sasikumar TK, Qiang L, Burnett DA, Greenlee WJ, Li C, Grilli M, Bertorelli R, Lozza G, Reggiani A. Sasikumar TK, et al. Among authors: lozza g. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2474-7. doi: 10.1016/j.bmcl.2010.03.004. Epub 2010 Mar 10. Bioorg Med Chem Lett. 2010. PMID: 20346665

4

Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain.

Bennett CE, Burnett DA, Greenlee WJ, Knutson CE, Korakas P, Li C, Tulshian D, Wu WL, Bertorelli R, Fredduzzi S, Grilli M, Lozza G, Reggiani A, Veltri A. Bennett CE, et al. Among authors: lozza g. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1575-8. doi: 10.1016/j.bmcl.2011.12.131. Epub 2012 Jan 3. Bioorg Med Chem Lett. 2012. PMID: 22266036

5

Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain.

Brumfield S, Korakas P, Silverman LS, Tulshian D, Matasi JJ, Qiang L, Bennett CE, Burnett DA, Greenlee WJ, Knutson CE, Wu WL, Sasikumar TK, Domalski M, Bertorelli R, Grilli M, Lozza G, Reggiani A, Li C. Brumfield S, et al. Among authors: lozza g. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7223-6. doi: 10.1016/j.bmcl.2012.09.048. Epub 2012 Oct 2. Bioorg Med Chem Lett. 2012. PMID: 23084894

6

Identification of single nucleotide polymorphisms of the human metabotropic glutamate receptor 1 gene and pharmacological characterization of a P993S variant.

Downey PM, Petrò R, Simon JS, Devlin D, Lozza G, Veltri A, Beltramo M, Bertorelli R, Reggiani A. Downey PM, et al. Among authors: lozza g. Biochem Pharmacol. 2009 Apr 1;77(7):1246-53. doi: 10.1016/j.bcp.2008.12.003. Epub 2008 Dec 25. Biochem Pharmacol. 2009. PMID: 19146831

7

Ecdysone-based system for controlled inducible expression of metabotropic glutamate receptor subtypes 2, 5, and 8.

Downey PM, Lozza G, Petrò R, Diodato E, Foglia C, Bottazzoli F, Brusa R, Asquini T, Reggiani A, Grilli M. Downey PM, et al. Among authors: lozza g. J Biomol Screen. 2005 Dec;10(8):841-8. doi: 10.1177/1087057105280285. Epub 2005 Oct 18. J Biomol Screen. 2005. PMID: 16234343

8

Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology.

Scandroglio P, Brusa R, Lozza G, Mancini I, Petrò R, Reggiani A, Beltramo M. Scandroglio P, et al. Among authors: lozza g. J Biomol Screen. 2010 Dec;15(10):1238-47. doi: 10.1177/1087057110375615. Epub 2010 Sep 1. J Biomol Screen. 2010. PMID: 20811068

9

Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice.

Hyde LA, Kazdoba TM, Grilli M, Lozza G, Brusa R, Zhang Q, Wong GT, McCool MF, Zhang L, Parker EM, Higgins GA. Hyde LA, et al. Among authors: lozza g. Behav Brain Res. 2005 May 28;160(2):344-55. doi: 10.1016/j.bbr.2004.12.017. Epub 2005 Feb 1. Behav Brain Res. 2005. PMID: 15863231

10

Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage.

Grilli M, Barbieri I, Basudev H, Brusa R, Casati C, Lozza G, Ongini E. Grilli M, et al. Among authors: lozza g. Eur J Neurosci. 2000 Jul;12(7):2265-72. doi: 10.1046/j.1460-9568.2000.00090.x. Eur J Neurosci. 2000. PMID: 10947805

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