Huang WH - Search Results

1

Progress in the development of nonpeptidomimetic BACE 1 inhibitors for Alzheimer's disease.

Huang WH, Sheng R, Hu YZ. Huang WH, et al. Curr Med Chem. 2009;16(14):1806-20. doi: 10.2174/092986709788186174. Curr Med Chem. 2009. PMID: 19442147 Review.

2

Identification of pharmacophore model, synthesis and biological evaluation of N-phenyl-1-arylamide and N-phenylbenzenesulfonamide derivatives as BACE 1 inhibitors.

Huang W, Yu H, Sheng R, Li J, Hu Y. Huang W, et al. Bioorg Med Chem. 2008 Dec 15;16(24):10190-7. doi: 10.1016/j.bmc.2008.10.059. Epub 2008 Oct 30. Bioorg Med Chem. 2008. PMID: 19013073

3

Design, synthesis, and quantitative structure-activity relationship of cytotoxic gamma-carboline derivatives.

Chen J, Dong X, Liu T, Lou J, Jiang C, Huang W, He Q, Yang B, Hu Y. Chen J, et al. Bioorg Med Chem. 2009 May 1;17(9):3324-31. doi: 10.1016/j.bmc.2009.03.037. Epub 2009 Mar 26. Bioorg Med Chem. 2009. PMID: 19359185

4

Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.

Sheng R, Lin X, Zhang J, Chol KS, Huang W, Yang B, He Q, Hu Y. Sheng R, et al. Bioorg Med Chem. 2009 Sep 15;17(18):6692-8. doi: 10.1016/j.bmc.2009.07.072. Epub 2009 Aug 3. Bioorg Med Chem. 2009. PMID: 19692250

5

Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease.

Huang W, Lv D, Yu H, Sheng R, Kim SC, Wu P, Luo K, Li J, Hu Y. Huang W, et al. Bioorg Med Chem. 2010 Aug 1;18(15):5610-5. doi: 10.1016/j.bmc.2010.06.042. Epub 2010 Jun 17. Bioorg Med Chem. 2010. PMID: 20620068

6

Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H₃R and BACE 1 inhibitory activities.

Huang W, Tang L, Shi Y, Huang S, Xu L, Sheng R, Wu P, Li J, Zhou N, Hu Y. Huang W, et al. Bioorg Med Chem. 2011 Dec 1;19(23):7158-67. doi: 10.1016/j.bmc.2011.09.061. Epub 2011 Oct 5. Bioorg Med Chem. 2011. PMID: 22019465

7

Identification of novel piperazinylquinoxaline derivatives as potent phosphoinositide 3-kinase (PI3K) inhibitors.

Wu P, Su Y, Guan X, Liu X, Zhang J, Dong X, Huang W, Hu Y. Wu P, et al. PLoS One. 2012;7(8):e43171. doi: 10.1371/journal.pone.0043171. Epub 2012 Aug 14. PLoS One. 2012. PMID: 22905224 Free PMC article.

8

Design, synthesis and evaluation of 3-(2-aminoheterocycle)-4-benzyloxyphenylbenzamide derivatives as BACE-1 inhibitors.

Shangguan S, Wang F, Liao Y, Yu H, Li J, Huang W, Hu H, Yu L, Hu Y, Sheng R. Shangguan S, et al. Molecules. 2013 Mar 20;18(3):3577-94. doi: 10.3390/molecules18033577. Molecules. 2013. PMID: 23519200 Free PMC article.

9

Development of the "hidden" multifunctional agents for Alzheimer's disease.

Huang W, Liang M, Li Q, Zheng X, Zhang C, Wang Q, Tang L, Zhang Z, Wang B, Shen Z. Huang W, et al. Eur J Med Chem. 2019 Sep 1;177:247-258. doi: 10.1016/j.ejmech.2019.05.051. Epub 2019 May 27. Eur J Med Chem. 2019. PMID: 31158742

10

Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation.

Zhi Y, Wang S, Huang W, Zeng S, Liang M, Zhang C, Ma Z, Wang Z, Zhang Z, Shen Z. Zhi Y, et al. Eur J Med Chem. 2019 Oct 1;179:502-514. doi: 10.1016/j.ejmech.2019.06.067. Epub 2019 Jun 28. Eur J Med Chem. 2019. PMID: 31276895

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