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Page 1
Design and optimization of renin inhibitors: Orally bioavailable alkyl amines.
Tice CM, Xu Z, Yuan J, Simpson RD, Cacatian ST, Flaherty PT, Zhao W, Guo J, Ishchenko A, Singh SB, Wu Z, Scott BB, Bukhtiyarov Y, Berbaum J, Mason J, Panemangalore R, Cappiello MG, Müller D, Harrison RK, McGeehan GM, Dillard LW, Baldwin JJ, Claremon DA. Tice CM, et al. Among authors: dillard lw. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3541-5. doi: 10.1016/j.bmcl.2009.04.140. Epub 2009 May 5. Bioorg Med Chem Lett. 2009. PMID: 19457666
Optimization of orally bioavailable alkyl amine renin inhibitors.
Xu Z, Cacatian S, Yuan J, Simpson RD, Jia L, Zhao W, Tice CM, Flaherty PT, Guo J, Ishchenko A, Singh SB, Wu Z, McKeever BM, Scott BB, Bukhtiyarov Y, Berbaum J, Mason J, Panemangalore R, Cappiello MG, Bentley R, Doe CP, Harrison RK, McGeehan GM, Dillard LW, Baldwin JJ, Claremon DA. Xu Z, et al. Among authors: dillard lw. Bioorg Med Chem Lett. 2010 Jan 15;20(2):694-9. doi: 10.1016/j.bmcl.2009.11.066. Epub 2009 Dec 1. Bioorg Med Chem Lett. 2010. PMID: 19959358
Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket.
Yuan J, Simpson RD, Zhao W, Tice CM, Xu Z, Cacatian S, Jia L, Flaherty PT, Guo J, Ishchenko A, Wu Z, McKeever BM, Scott BB, Bukhtiyarov Y, Berbaum J, Panemangalore R, Bentley R, Doe CP, Harrison RK, McGeehan GM, Singh SB, Dillard LW, Baldwin JJ, Claremon DA. Yuan J, et al. Among authors: dillard lw. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4836-43. doi: 10.1016/j.bmcl.2011.06.043. Epub 2011 Jun 17. Bioorg Med Chem Lett. 2011. PMID: 21741239
Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.
Jia L, Simpson RD, Yuan J, Xu Z, Zhao W, Cacatian S, Tice CM, Guo J, Ishchenko A, Singh SB, Wu Z, McKeever BM, Bukhtiyarov Y, Johnson JA, Doe CP, Harrison RK, McGeehan GM, Dillard LW, Baldwin JJ, Claremon DA. Jia L, et al. Among authors: dillard lw. ACS Med Chem Lett. 2011 Aug 9;2(10):747-51. doi: 10.1021/ml200137x. eCollection 2011 Oct 13. ACS Med Chem Lett. 2011. PMID: 24900262 Free PMC article.
Cloning, characterization and site-directed mutagenesis of canine renin.
Bukhtiyarov Y, Zecher M, Panemangalore R, Wu Z, Bruno JG, Yuan J, Xu Z, Dillard LW, McGeehan GM, Harrison RK, Scott BB. Bukhtiyarov Y, et al. Among authors: dillard lw. J Biochem. 2007 Dec;142(6):671-80. doi: 10.1093/jb/mvm182. Epub 2007 Oct 17. J Biochem. 2007. PMID: 17942478
A paradigm for drug discovery employing encoded combinatorial libraries.
Burbaum JJ, Ohlmeyer MH, Reader JC, Henderson I, Dillard LW, Li G, Randle TL, Sigal NH, Chelsky D, Baldwin JJ. Burbaum JJ, et al. Among authors: dillard lw. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6027-31. doi: 10.1073/pnas.92.13.6027. Proc Natl Acad Sci U S A. 1995. PMID: 7597074 Free PMC article.
Complex synthetic chemical libraries indexed with molecular tags.
Ohlmeyer MH, Swanson RN, Dillard LW, Reader JC, Asouline G, Kobayashi R, Wigler M, Still WC. Ohlmeyer MH, et al. Among authors: dillard lw. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10922-6. doi: 10.1073/pnas.90.23.10922. Proc Natl Acad Sci U S A. 1993. PMID: 7504286 Free PMC article.