Okuzumi T - Search Results

1

Okuzumi T, Fiedler D, Zhang C, Gray DC, Aizenstein B, Hoffman R, Shokat KM. Okuzumi T, et al. Nat Chem Biol. 2009 Jul;5(7):484-93. doi: 10.1038/nchembio.183. Epub 2009 May 24. Nat Chem Biol. 2009. PMID: 19465931 Free PMC article.

2

Synthesis and evaluation of indazole based analog sensitive Akt inhibitors.

Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat KM. Okuzumi T, et al. Mol Biosyst. 2010 Aug;6(8):1389-402. doi: 10.1039/c003917a. Epub 2010 Jun 28. Mol Biosyst. 2010. PMID: 20582381 Free PMC article.

3

Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates.

Watanabe T, Arashida N, Fujii T, Shikida N, Ito K, Shimbo K, Seki T, Iwai Y, Hirama R, Hatada N, Nakayama A, Okuzumi T, Matsuda Y. Watanabe T, et al. Among authors: okuzumi t. J Med Chem. 2024 Oct 24;67(20):18124-18138. doi: 10.1021/acs.jmedchem.4c01251. Epub 2024 Oct 15. J Med Chem. 2024. PMID: 39410752 Free PMC article.

4

AJICAP-M: Traceless Affinity Peptide Mediated Conjugation Technology for Site-Selective Antibody-Drug Conjugate Synthesis.

Matsuda Y, Shikida N, Hatada N, Yamada K, Seki T, Nakahara Y, Endo Y, Shimbo K, Takahashi K, Nakayama A, Mendelsohn BA, Fujii T, Okuzumi T, Hirasawa S. Matsuda Y, et al. Among authors: okuzumi t. Org Lett. 2024 Jul 12;26(27):5597-5601. doi: 10.1021/acs.orglett.4c00878. Epub 2024 Apr 19. Org Lett. 2024. PMID: 38639400

5

AJICAP Second Generation: Improved Chemical Site-Specific Conjugation Technology for Antibody-Drug Conjugate Production.

Fujii T, Matsuda Y, Seki T, Shikida N, Iwai Y, Ooba Y, Takahashi K, Isokawa M, Kawaguchi S, Hatada N, Watanabe T, Takasugi R, Nakayama A, Shimbo K, Mendelsohn BA, Okuzumi T, Yamada K. Fujii T, et al. Among authors: okuzumi t. Bioconjug Chem. 2023 Mar 9;34(4):728-38. doi: 10.1021/acs.bioconjchem.3c00040. Online ahead of print. Bioconjug Chem. 2023. PMID: 36894324 Free PMC article.

6

Biological Evaluation of Maytansinoid-Based Site-Specific Antibody-Drug Conjugate Produced by Fully Chemical Conjugation Approach: AJICAP®.

Seki T, Yamada K, Ooba Y, Fujii T, Narita T, Nakayama A, Kitahara Y, Mendelsohn BA, Matsuda Y, Okuzumi T. Seki T, et al. Among authors: okuzumi t. Front Biosci (Landmark Ed). 2022 Aug 5;27(8):234. doi: 10.31083/j.fbl2708234. Front Biosci (Landmark Ed). 2022. PMID: 36042175 Free article.

7

Chemical Site-Specific Conjugation Platform to Improve the Pharmacokinetics and Therapeutic Index of Antibody-Drug Conjugates.

Matsuda Y, Seki T, Yamada K, Ooba Y, Takahashi K, Fujii T, Kawaguchi S, Narita T, Nakayama A, Kitahara Y, Mendelsohn BA, Okuzumi T. Matsuda Y, et al. Among authors: okuzumi t. Mol Pharm. 2021 Nov 1;18(11):4058-4066. doi: 10.1021/acs.molpharmaceut.1c00473. Epub 2021 Sep 27. Mol Pharm. 2021. PMID: 34579528 Free article.

8

Chromatographic analysis of site-specific antibody-drug conjugates produced by AJICAP first-generation technology using a recombinant FcγIIIa receptor-ligand affinity column.

Matsuda Y, Chakrabarti A, Takahashi K, Yamada K, Nakata K, Okuzumi T, Mendelsohn BA. Matsuda Y, et al. Among authors: okuzumi t. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jul 1;1177:122753. doi: 10.1016/j.jchromb.2021.122753. Epub 2021 May 19. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 34098178

9

A Purification Strategy Utilizing Hydrophobic Interaction Chromatography to Obtain Homogeneous Species from a Site-Specific Antibody Drug Conjugate Produced by AJICAP™ First Generation.

Matsuda Y, Leung M, Okuzumi T, Mendelsohn B. Matsuda Y, et al. Among authors: okuzumi t. Antibodies (Basel). 2020 May 18;9(2):16. doi: 10.3390/antib9020016. Antibodies (Basel). 2020. PMID: 32443479 Free PMC article.

10

Efficient solid-phase synthesis of diverse 2-aminoquinazolin-4-ones from resin-bound anilines.

Makino S, Okuzumi T, Tsuji T, Nakanishi E. Makino S, et al. Among authors: okuzumi t. J Comb Chem. 2003 Nov-Dec;5(6):756-9. doi: 10.1021/cc030033l. J Comb Chem. 2003. PMID: 14606802 No abstract available.

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