Pinto LH - Search Results

1

Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus.

Wang J, Cady SD, Balannik V, Pinto LH, DeGrado WF, Hong M. Wang J, et al. Among authors: pinto lh. J Am Chem Soc. 2009 Jun 17;131(23):8066-76. doi: 10.1021/ja900063s. J Am Chem Soc. 2009. PMID: 19469531 Free PMC article.

2

The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus.

Stouffer AL, Ma C, Cristian L, Ohigashi Y, Lamb RA, Lear JD, Pinto LH, DeGrado WF. Stouffer AL, et al. Among authors: pinto lh. Structure. 2008 Jul;16(7):1067-76. doi: 10.1016/j.str.2008.04.011. Structure. 2008. PMID: 18611380 Free PMC article.

3

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus.

Balannik V, Wang J, Ohigashi Y, Jing X, Magavern E, Lamb RA, Degrado WF, Pinto LH. Balannik V, et al. Among authors: pinto lh. Biochemistry. 2009 Dec 22;48(50):11872-82. doi: 10.1021/bi9014488. Biochemistry. 2009. PMID: 19905033 Free PMC article.

4

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.

Acharya R, Carnevale V, Fiorin G, Levine BG, Polishchuk AL, Balannik V, Samish I, Lamb RA, Pinto LH, DeGrado WF, Klein ML. Acharya R, et al. Among authors: pinto lh. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15075-80. doi: 10.1073/pnas.1007071107. Epub 2010 Aug 5. Proc Natl Acad Sci U S A. 2010. PMID: 20689043 Free PMC article.

5

A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein.

Polishchuk AL, Lear JD, Ma C, Lamb RA, Pinto LH, Degrado WF. Polishchuk AL, et al. Among authors: pinto lh. Biochemistry. 2010 Nov 30;49(47):10061-71. doi: 10.1021/bi101229m. Epub 2010 Nov 3. Biochemistry. 2010. PMID: 20968306 Free PMC article.

6

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus.

Wang J, Ma C, Balannik V, Pinto LH, Lamb RA, Degrado WF. Wang J, et al. Among authors: pinto lh. ACS Med Chem Lett. 2011 Apr 14;2(4):307-312. doi: 10.1021/ml100297w. ACS Med Chem Lett. 2011. PMID: 21691418 Free PMC article.

7

Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.

Wang J, Ma C, Fiorin G, Carnevale V, Wang T, Hu F, Lamb RA, Pinto LH, Hong M, Klein ML, DeGrado WF. Wang J, et al. Among authors: pinto lh. J Am Chem Soc. 2011 Aug 17;133(32):12834-41. doi: 10.1021/ja204969m. Epub 2011 Jul 21. J Am Chem Soc. 2011. PMID: 21744829 Free PMC article.

8

Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel.

Wang J, Ma C, Wu Y, Lamb RA, Pinto LH, DeGrado WF. Wang J, et al. Among authors: pinto lh. J Am Chem Soc. 2011 Sep 7;133(35):13844-7. doi: 10.1021/ja2050666. Epub 2011 Aug 12. J Am Chem Soc. 2011. PMID: 21819109 Free PMC article.

9

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.

Wang J, Wu Y, Ma C, Fiorin G, Wang J, Pinto LH, Lamb RA, Klein ML, Degrado WF. Wang J, et al. Among authors: pinto lh. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1315-20. doi: 10.1073/pnas.1216526110. Epub 2013 Jan 9. Proc Natl Acad Sci U S A. 2013. PMID: 23302696 Free PMC article.

10

Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.

Wang J, Ma C, Wang J, Jo H, Canturk B, Fiorin G, Pinto LH, Lamb RA, Klein ML, DeGrado WF. Wang J, et al. Among authors: pinto lh. J Med Chem. 2013 Apr 11;56(7):2804-12. doi: 10.1021/jm301538e. Epub 2013 Mar 27. J Med Chem. 2013. PMID: 23437766 Free PMC article.

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