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Novel leads from Heliotropium ovalifolium, 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6-hydroxy-5,7-dimethoxy-naphthalene-2-carbaldehyde show specific IL-6 inhibitory activity in THP-1 cells and primary human monocytes.
Kulkarni-Almeida A, Suthar A, Goswami H, Vishwakarma R, Chauhan VS, Balakrishnan A, Sharma S. Kulkarni-Almeida A, et al. Among authors: balakrishnan a. Phytomedicine. 2008 Dec;15(12):1079-86. doi: 10.1016/j.phymed.2008.04.013. Epub 2008 Jun 25. Phytomedicine. 2008. PMID: 18583119
Anticancer activity of koningic acid and semisynthetic derivatives.
Rahier NJ, Molinier N, Long C, Deshmukh SK, Kate AS, Ranadive P, Verekar SA, Jiotode M, Lavhale RR, Tokdar P, Balakrishnan A, Meignan S, Robichon C, Gomes B, Aussagues Y, Samson A, Sautel F, Bailly C. Rahier NJ, et al. Among authors: balakrishnan a. Bioorg Med Chem. 2015 Jul 1;23(13):3712-21. doi: 10.1016/j.bmc.2015.04.004. Epub 2015 Apr 9. Bioorg Med Chem. 2015. PMID: 25937235
Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists.
Bharate SB, Rodge A, Joshi RK, Kaur J, Srinivasan S, Kumar SS, Kulkarni-Almeida A, Balachandran S, Balakrishnan A, Vishwakarma RA. Bharate SB, et al. Among authors: balakrishnan a. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6357-61. doi: 10.1016/j.bmcl.2008.10.085. Epub 2008 Nov 1. Bioorg Med Chem Lett. 2008. PMID: 18993064
7-Hydroxy Frullanolide, a sesquiterpene lactone, increases intracellular calcium amounts, lowers CD4+ T cell and macrophage responses, and ameliorates DSS-induced colitis.
Pathak S, Gokhroo A, Kumar Dubey A, Majumdar S, Gupta S, Almeida A, Mahajan GB, Kate A, Mishra P, Sharma R, Kumar S, Vishwakarma R, Balakrishnan A, Atreya H, Nandi D. Pathak S, et al. Among authors: balakrishnan a. Int Immunopharmacol. 2021 Aug;97:107655. doi: 10.1016/j.intimp.2021.107655. Epub 2021 Apr 24. Int Immunopharmacol. 2021. PMID: 33901737
Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells.
Ponnurangam S, Dandawate PR, Dhar A, Tawfik OW, Parab RR, Mishra PD, Ranadive P, Sharma R, Mahajan G, Umar S, Weir SJ, Sugumar A, Jensen RA, Padhye SB, Balakrishnan A, Anant S, Subramaniam D. Ponnurangam S, et al. Among authors: balakrishnan a. Oncotarget. 2016 Jan 19;7(3):3217-32. doi: 10.18632/oncotarget.6560. Oncotarget. 2016. PMID: 26673007 Free PMC article.
585 results