Stegeman RA - Search Results

1

Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.

Xing L, Shieh HS, Selness SR, Devraj RV, Walker JK, Devadas B, Hope HR, Compton RP, Schindler JF, Hirsch JL, Benson AG, Kurumbail RG, Stegeman RA, Williams JM, Broadus RM, Walden Z, Monahan JB. Xing L, et al. Among authors: stegeman ra. Biochemistry. 2009 Jul 14;48(27):6402-11. doi: 10.1021/bi900655f. Biochemistry. 2009. PMID: 19496616

2

Synthesis and X-ray crystal structures of substituted fluorobenzene and benzoquinone inhibitors of the tissue factor VIIa complex.

Parlow JJ, Kurumbail RG, Stegeman RA, Stevens AM, Stallings WC, South MS. Parlow JJ, et al. Among authors: stegeman ra. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3721-5. doi: 10.1016/j.bmcl.2003.08.002. Bioorg Med Chem Lett. 2003. PMID: 14552766

3

Design, synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors.

Parlow JJ, Kurumbail RG, Stegeman RA, Stevens AM, Stallings WC, South MS. Parlow JJ, et al. Among authors: stegeman ra. J Med Chem. 2003 Oct 23;46(22):4696-701. doi: 10.1021/jm0301686. J Med Chem. 2003. PMID: 14561089

4

2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor.

Trujillo JI, Kiefer JR, Huang W, Thorarensen A, Xing L, Caspers NL, Day JE, Mathis KJ, Kretzmer KK, Reitz BA, Weinberg RA, Stegeman RA, Wrightstone A, Christine L, Compton R, Li X. Trujillo JI, et al. Among authors: stegeman ra. Bioorg Med Chem Lett. 2009 Feb 1;19(3):908-11. doi: 10.1016/j.bmcl.2008.11.105. Epub 2008 Dec 6. Bioorg Med Chem Lett. 2009. PMID: 19097791

5

Synthesis and crystal structures of substituted benzenes and benzoquinones as tissue factor VIIa inhibitors.

Parlow JJ, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, South MS. Parlow JJ, et al. Among authors: stegeman ra. J Med Chem. 2003 Sep 25;46(20):4297-312. doi: 10.1021/jm030233b. J Med Chem. 2003. PMID: 13678408

6

Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors.

Parlow JJ, Dice TA, Lachance RM, Girard TJ, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, South MS. Parlow JJ, et al. Among authors: stegeman ra. J Med Chem. 2003 Sep 11;46(19):4043-9. doi: 10.1021/jm030130t. J Med Chem. 2003. PMID: 12954057

7

Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa.

Schweitzer BA, Neumann WL, Rahman HK, Kusturin CL, Sample KR, Poda GI, Kurumbail RG, Stevens AM, Stegeman RA, Stallings WC, South MS. Schweitzer BA, et al. Among authors: stegeman ra. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3006-11. doi: 10.1016/j.bmcl.2005.04.037. Bioorg Med Chem Lett. 2005. PMID: 15913999

8

Synthesis and identification of conformationally constrained selective MMP inhibitors.

Freskos JN, McDonald JJ, Mischke BV, Mullins PB, Shieh HS, Stegeman RA, Stevens AM. Freskos JN, et al. Among authors: stegeman ra. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. doi: 10.1016/s0960-894x(99)00285-1. Bioorg Med Chem Lett. 1999. PMID: 10406637

9

Three-dimensional structure of human cytomegalovirus protease.

Shieh HS, Kurumbail RG, Stevens AM, Stegeman RA, Sturman EJ, Pak JY, Wittwer AJ, Palmier MO, Wiegand RC, Holwerda BC, Stallings WC. Shieh HS, et al. Among authors: stegeman ra. Nature. 1996 Sep 19;383(6597):279-82. doi: 10.1038/383279a0. Nature. 1996. PMID: 8805708

10

Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.

South MS, Case BL, Wood RS, Jones DE, Hayes MJ, Girard TJ, Lachance RM, Nicholson NS, Clare M, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, Parlow JJ. South MS, et al. Among authors: stegeman ra. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2319-25. doi: 10.1016/s0960-894x(03)00410-4. Bioorg Med Chem Lett. 2003. PMID: 12824026

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