Lavelle D - Search Results

1

Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues.

Araki H, Baluchamy S, Yoshinaga K, Petro B, Petiwala S, Parajuli R, Milhem M, Lavelle D, DeSimone J, Mahmud N. Araki H, et al. Among authors: lavelle d. Exp Hematol. 2009 Sep;37(9):1084-95. doi: 10.1016/j.exphem.2009.05.012. Epub 2009 Jun 6. Exp Hematol. 2009. PMID: 19501128 Free PMC article.

2

Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A.

Milhem M, Mahmud N, Lavelle D, Araki H, DeSimone J, Saunthararajah Y, Hoffman R. Milhem M, et al. Among authors: lavelle d. Blood. 2004 Jun 1;103(11):4102-10. doi: 10.1182/blood-2003-07-2431. Epub 2004 Feb 19. Blood. 2004. PMID: 14976039 Free article.

3

The gamma-globin gene promoter progressively demethylates as the hematopoietic stem progenitor cells differentiate along the erythroid lineage in baboon fetal liver and adult bone marrow.

Singh M, Lavelle D, Vaitkus K, Mahmud N, Hankewych M, DeSimone J. Singh M, et al. Among authors: lavelle d. Exp Hematol. 2007 Jan;35(1):48-55. doi: 10.1016/j.exphem.2006.09.001. Exp Hematol. 2007. PMID: 17198873 Free article.

4

Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms.

Chin J, Singh M, Banzon V, Vaitkus K, Ibanez V, Kouznetsova T, Mahmud N, DeSimone J, Lavelle D. Chin J, et al. Among authors: lavelle d. Exp Hematol. 2009 Oct;37(10):1131-42. doi: 10.1016/j.exphem.2009.06.007. Epub 2009 Jul 2. Exp Hematol. 2009. PMID: 19576949 Free PMC article.

5

Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells.

Mahmud N, Petro B, Baluchamy S, Li X, Taioli S, Lavelle D, Quigley JG, Suphangul M, Araki H. Mahmud N, et al. Among authors: lavelle d. Biol Blood Marrow Transplant. 2014 Apr;20(4):480-9. doi: 10.1016/j.bbmt.2013.12.562. Epub 2013 Dec 26. Biol Blood Marrow Transplant. 2014. PMID: 24374212 Free PMC article.

6

DNA hypo-methylating agents and sickle cell disease.

Saunthararajah Y, Lavelle D, DeSimone J. Saunthararajah Y, et al. Among authors: lavelle d. Br J Haematol. 2004 Sep;126(5):629-36. doi: 10.1111/j.1365-2141.2004.05064.x. Br J Haematol. 2004. PMID: 15327513 Free article. Review.

7

Effect of 5-aza-2'-deoxycytidine (Dacogen) on covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin promoters in Papio anubis.

Lavelle D, Vaitkus K, Hankewych M, Singh M, DeSimone J. Lavelle D, et al. Exp Hematol. 2006 Mar;34(3):339-47. doi: 10.1016/j.exphem.2005.12.010. Exp Hematol. 2006. PMID: 16543068 Free article.

8

Decitabine increases fetal hemoglobin in Papio anubis by increasing γ-globin gene transcription.

Akpan I, Banzon V, Ibanez V, Vaitkus K, DeSimone J, Lavelle D. Akpan I, et al. Among authors: lavelle d. Exp Hematol. 2010 Nov;38(11):989-993.e1. doi: 10.1016/j.exphem.2010.08.001. Epub 2010 Aug 14. Exp Hematol. 2010. PMID: 20713129 Free PMC article.

9

siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)-dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures.

Banzon V, Ibanez V, Vaitkus K, Ruiz MA, Peterson K, DeSimone J, Lavelle D. Banzon V, et al. Among authors: lavelle d. Exp Hematol. 2011 Jan;39(1):26-36.e1. doi: 10.1016/j.exphem.2010.10.003. Epub 2010 Oct 23. Exp Hematol. 2011. PMID: 20974210 Free PMC article.

10

RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model.

Rivers A, Vaitkus K, Ruiz MA, Ibanez V, Jagadeeswaran R, Kouznetsova T, DeSimone J, Lavelle D. Rivers A, et al. Among authors: lavelle d. Exp Hematol. 2015 Jul;43(7):546-53.e1-3. doi: 10.1016/j.exphem.2015.04.005. Epub 2015 Apr 27. Exp Hematol. 2015. PMID: 25931013 Free PMC article.

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