Lee WC - Search Results

1

An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer.

Rausch MP, Hahn T, Ramanathapuram L, Bradley-Dunlop D, Mahadevan D, Mercado-Pimentel ME, Runyan RB, Besselsen DG, Zhang X, Cheung HK, Lee WC, Ling LE, Akporiaye ET. Rausch MP, et al. Among authors: lee wc. Anticancer Res. 2009 Jun;29(6):2099-109. Anticancer Res. 2009. PMID: 19528470 Free PMC article.

2

A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection.

Suzuki E, Kim S, Cheung HK, Corbley MJ, Zhang X, Sun L, Shan F, Singh J, Lee WC, Albelda SM, Ling LE. Suzuki E, et al. Among authors: lee wc. Cancer Res. 2007 Mar 1;67(5):2351-9. doi: 10.1158/0008-5472.CAN-06-2389. Cancer Res. 2007. PMID: 17332368

3

Tgf-beta type I receptor (Alk5) kinase inhibitors in oncology.

Ling LE, Lee WC. Ling LE, et al. Among authors: lee wc. Curr Pharm Biotechnol. 2011 Dec;12(12):2190-202. doi: 10.2174/138920111798808257. Curr Pharm Biotechnol. 2011. PMID: 21619541 Review.

4

The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis.

Garrison K, Hahn T, Lee WC, Ling LE, Weinberg AD, Akporiaye ET. Garrison K, et al. Among authors: lee wc. Cancer Immunol Immunother. 2012 Apr;61(4):511-21. doi: 10.1007/s00262-011-1119-y. Epub 2011 Oct 5. Cancer Immunol Immunother. 2012. PMID: 21971588 Free PMC article.

5

SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model.

Fu K, Corbley MJ, Sun L, Friedman JE, Shan F, Papadatos JL, Costa D, Lutterodt F, Sweigard H, Bowes S, Choi M, Boriack-Sjodin PA, Arduini RM, Sun D, Newman MN, Zhang X, Mead JN, Chuaqui CE, Cheung HK, Zhang X, Cornebise M, Carter MB, Josiah S, Singh J, Lee WC, Gill A, Ling LE. Fu K, et al. Among authors: lee wc. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):665-71. doi: 10.1161/ATVBAHA.107.158030. Epub 2008 Jan 17. Arterioscler Thromb Vasc Biol. 2008. PMID: 18202322

6

Transforming the TGFbeta pathway: convergence of distinct lead generation strategies on a novel kinase pharmacophore for TbetaRI (ALK5).

Singh J, Ling LE, Sawyer JS, Lee WC, Zhang F, Yingling JM. Singh J, et al. Among authors: lee wc. Curr Opin Drug Discov Devel. 2004 Jul;7(4):437-45. Curr Opin Drug Discov Devel. 2004. PMID: 15338953 Review.

7

Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury.

Anscher MS, Thrasher B, Zgonjanin L, Rabbani ZN, Corbley MJ, Fu K, Sun L, Lee WC, Ling LE, Vujaskovic Z. Anscher MS, et al. Among authors: lee wc. Int J Radiat Oncol Biol Phys. 2008 Jul 1;71(3):829-37. doi: 10.1016/j.ijrobp.2008.02.046. Epub 2008 Apr 12. Int J Radiat Oncol Biol Phys. 2008. PMID: 18411002

8

Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo.

Ishida W, Mori Y, Lakos G, Sun L, Shan F, Bowes S, Josiah S, Lee WC, Singh J, Ling LE, Varga J. Ishida W, et al. Among authors: lee wc. J Invest Dermatol. 2006 Aug;126(8):1733-44. doi: 10.1038/sj.jid.5700303. Epub 2006 Jun 1. J Invest Dermatol. 2006. PMID: 16741519 Free article.

9

Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI).

Singh J, Chuaqui CE, Boriack-Sjodin PA, Lee WC, Pontz T, Corbley MJ, Cheung HK, Arduini RM, Mead JN, Newman MN, Papadatos JL, Bowes S, Josiah S, Ling LE. Singh J, et al. Among authors: lee wc. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4355-9. doi: 10.1016/j.bmcl.2003.09.028. Bioorg Med Chem Lett. 2003. PMID: 14643325

10

2-Aminoimidazoles inhibitors of TGF-beta receptor 1.

Bonafoux D, Chuaqui C, Boriack-Sjodin PA, Fitch C, Hankins G, Josiah S, Black C, Hetu G, Ling L, Lee WC. Bonafoux D, et al. Among authors: lee wc. Bioorg Med Chem Lett. 2009 Feb 1;19(3):912-6. doi: 10.1016/j.bmcl.2008.11.119. Epub 2008 Dec 11. Bioorg Med Chem Lett. 2009. PMID: 19135364

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