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A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.
Prime TA, Blaikie FH, Evans C, Nadtochiy SM, James AM, Dahm CC, Vitturi DA, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani ET, Hurd TR, Garvey JF, Taylor CT, Brookes PS, Smith RA, Murphy MP. Prime TA, et al. Among authors: blaikie fh. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10764-9. doi: 10.1073/pnas.0903250106. Epub 2009 Jun 15. Proc Natl Acad Sci U S A. 2009. PMID: 19528654 Free PMC article.
Specific targeting of a DNA-alkylating reagent to mitochondria. Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide.
James AM, Blaikie FH, Smith RA, Lightowlers RN, Smith PM, Murphy MP. James AM, et al. Among authors: blaikie fh. Eur J Biochem. 2003 Jul;270(13):2827-36. doi: 10.1046/j.1432-1033.2003.03660.x. Eur J Biochem. 2003. PMID: 12823553 Free article.
Accumulation of lipophilic dications by mitochondria and cells.
Ross MF, Da Ros T, Blaikie FH, Prime TA, Porteous CM, Severina II, Skulachev VP, Kjaergaard HG, Smith RA, Murphy MP. Ross MF, et al. Among authors: blaikie fh. Biochem J. 2006 Nov 15;400(1):199-208. doi: 10.1042/BJ20060919. Biochem J. 2006. PMID: 16948637 Free PMC article.
Mitochondrial targeting of quinones: therapeutic implications.
Cochemé HM, Kelso GF, James AM, Ross MF, Trnka J, Mahendiran T, Asin-Cayuela J, Blaikie FH, Manas AR, Porteous CM, Adlam VJ, Smith RA, Murphy MP. Cochemé HM, et al. Among authors: blaikie fh. Mitochondrion. 2007 Jun;7 Suppl:S94-102. doi: 10.1016/j.mito.2007.02.007. Epub 2007 Mar 16. Mitochondrion. 2007. PMID: 17449335 Review.
Antioxidant properties of MitoTEMPOL and its hydroxylamine.
Trnka J, Blaikie FH, Logan A, Smith RA, Murphy MP. Trnka J, et al. Among authors: blaikie fh. Free Radic Res. 2009 Jan;43(1):4-12. doi: 10.1080/10715760802582183. Free Radic Res. 2009. PMID: 19058062 Free PMC article.
Mitochondria-targeted antioxidants in the treatment of disease.
Smith RA, Adlam VJ, Blaikie FH, Manas AR, Porteous CM, James AM, Ross MF, Logan A, Cochemé HM, Trnka J, Prime TA, Abakumova I, Jones BA, Filipovska A, Murphy MP. Smith RA, et al. Among authors: blaikie fh. Ann N Y Acad Sci. 2008 Dec;1147:105-11. doi: 10.1196/annals.1427.003. Ann N Y Acad Sci. 2008. PMID: 19076435 Review.
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone.
Murphy MP, Echtay KS, Blaikie FH, Asin-Cayuela J, Cocheme HM, Green K, Buckingham JA, Taylor ER, Hurrell F, Hughes G, Miwa S, Cooper CE, Svistunenko DA, Smith RA, Brand MD. Murphy MP, et al. Among authors: blaikie fh. J Biol Chem. 2003 Dec 5;278(49):48534-45. doi: 10.1074/jbc.M308529200. Epub 2003 Sep 12. J Biol Chem. 2003. PMID: 12972420 Free article.
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