Donnelly-Roberts DL - Search Results

1

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.

Donnelly-Roberts DL, Namovic MT, Han P, Jarvis MF. Donnelly-Roberts DL, et al. Br J Pharmacol. 2009 Aug;157(7):1203-14. doi: 10.1111/j.1476-5381.2009.00233.x. Epub 2009 Jun 22. Br J Pharmacol. 2009. PMID: 19558545 Free PMC article.

2

A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat.

Honore P, Donnelly-Roberts D, Namovic MT, Hsieh G, Zhu CZ, Mikusa JP, Hernandez G, Zhong C, Gauvin DM, Chandran P, Harris R, Medrano AP, Carroll W, Marsh K, Sullivan JP, Faltynek CR, Jarvis MF. Honore P, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):1376-85. doi: 10.1124/jpet.106.111559. Epub 2006 Sep 18. J Pharmacol Exp Ther. 2006. PMID: 16982702

3

Painful purinergic receptors.

Donnelly-Roberts D, McGaraughty S, Shieh CC, Honore P, Jarvis MF. Donnelly-Roberts D, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):409-15. doi: 10.1124/jpet.106.105890. Epub 2007 Nov 27. J Pharmacol Exp Ther. 2008. PMID: 18042830 Review.

4

The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice.

Honore P, Donnelly-Roberts D, Namovic M, Zhong C, Wade C, Chandran P, Zhu C, Carroll W, Perez-Medrano A, Iwakura Y, Jarvis MF. Honore P, et al. Behav Brain Res. 2009 Dec 1;204(1):77-81. doi: 10.1016/j.bbr.2009.05.018. Epub 2009 May 21. Behav Brain Res. 2009. PMID: 19464323

5

High throughput functional assays for P2X receptors.

Namovic MT, Jarvis MF, Donnelly-Roberts D. Namovic MT, et al. Curr Protoc Pharmacol. 2012 Jun;Chapter 9:Unit 9.15.. doi: 10.1002/0471141755.ph0915s57. Curr Protoc Pharmacol. 2012. PMID: 22684723

6

Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cells.

Donnelly-Roberts DL, Namovic MT, Faltynek CR, Jarvis MF. Donnelly-Roberts DL, et al. J Pharmacol Exp Ther. 2004 Mar;308(3):1053-61. doi: 10.1124/jpet.103.059600. Epub 2003 Nov 21. J Pharmacol Exp Ther. 2004. PMID: 14634045

7

Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5).

Moreland RB, Nakane M, Donnelly-Roberts DL, Miller LN, Chang R, Uchic ME, Terranova MA, Gubbins EJ, Helfrich RJ, Namovic MT, El-Kouhen OF, Masters JN, Brioni JD. Moreland RB, et al. Biochem Pharmacol. 2004 Aug 15;68(4):761-72. doi: 10.1016/j.bcp.2004.05.019. Biochem Pharmacol. 2004. PMID: 15276084

8

Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.

Nelson DW, Gregg RJ, Kort ME, Perez-Medrano A, Voight EA, Wang Y, Grayson G, Namovic MT, Donnelly-Roberts DL, Niforatos W, Honore P, Jarvis MF, Faltynek CR, Carroll WA. Nelson DW, et al. J Med Chem. 2006 Jun 15;49(12):3659-66. doi: 10.1021/jm051202e. J Med Chem. 2006. PMID: 16759108

9

Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists.

Carroll WA, Kalvin DM, Perez Medrano A, Florjancic AS, Wang Y, Donnelly-Roberts DL, Namovic MT, Grayson G, Honoré P, Jarvis MF. Carroll WA, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4044-8. doi: 10.1016/j.bmcl.2007.04.075. Epub 2007 Apr 27. Bioorg Med Chem Lett. 2007. PMID: 17482819

10

Synthesis and in vitro activity of N'-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists.

Morytko MJ, Betschmann P, Woller K, Ericsson A, Chen H, Donnelly-Roberts DL, Namovic MT, Jarvis MF, Carroll WA, Rafferty P. Morytko MJ, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2093-6. doi: 10.1016/j.bmcl.2008.01.094. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18272365

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