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Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice.
Hamilton-Williams EE, Martinez X, Clark J, Howlett S, Hunter KM, Rainbow DB, Wen L, Shlomchik MJ, Katz JD, Beilhack GF, Wicker LS, Sherman LA. Hamilton-Williams EE, et al. Among authors: beilhack gf. J Immunol. 2009 Aug 1;183(3):1533-41. doi: 10.4049/jimmunol.0900428. Epub 2009 Jul 10. J Immunol. 2009. PMID: 19592648 Free PMC article.
Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes.
Chaparro RJ, Konigshofer Y, Beilhack GF, Shizuru JA, McDevitt HO, Chien YH. Chaparro RJ, et al. Among authors: beilhack gf. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12475-80. doi: 10.1073/pnas.0604317103. Epub 2006 Aug 8. Proc Natl Acad Sci U S A. 2006. PMID: 16895987 Free PMC article.
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Onengut-Gumuscu S, Chen WM, Burren O, Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E, Bonnie JK, Szpak M, Schofield E, Achuthan P, Guo H, Fortune MD, Stevens H, Walker NM, Ward LD, Kundaje A, Kellis M, Daly MJ, Barrett JC, Cooper JD, Deloukas P; Type 1 Diabetes Genetics Consortium; Todd JA, Wallace C, Concannon P, Rich SS. Onengut-Gumuscu S, et al. Nat Genet. 2015 Apr;47(4):381-6. doi: 10.1038/ng.3245. Epub 2015 Mar 9. Nat Genet. 2015. PMID: 25751624 Free PMC article.
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