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Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile.
Silvestri R, Ligresti A, La Regina G, Piscitelli F, Gatti V, Brizzi A, Pasquini S, Lavecchia A, Allarà M, Fantini N, Carai MA, Novellino E, Colombo G, Di Marzo V, Corelli F. Silvestri R, et al. Among authors: fantini n. Bioorg Med Chem. 2009 Aug 1;17(15):5549-64. doi: 10.1016/j.bmc.2009.06.027. Epub 2009 Jun 21. Bioorg Med Chem. 2009. PMID: 19595596
Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.
Silvestri R, Ligresti A, La Regina G, Piscitelli F, Gatti V, Lavecchia A, Brizzi A, Pasquini S, Allarà M, Fantini N, Carai MA, Bigogno C, Rozio MG, Sinisi R, Novellino E, Colombo G, Di Marzo V, Dondio G, Corelli F. Silvestri R, et al. Among authors: fantini n. Eur J Med Chem. 2010 Dec;45(12):5878-86. doi: 10.1016/j.ejmech.2010.09.053. Epub 2010 Oct 1. Eur J Med Chem. 2010. PMID: 20943290
16 results