Zupi G - Search Results

1

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.

Rizzo A, Salvati E, Porru M, D'Angelo C, Stevens MF, D'Incalci M, Leonetti C, Gilson E, Zupi G, Biroccio A. Rizzo A, et al. Among authors: zupi g. Nucleic Acids Res. 2009 Sep;37(16):5353-64. doi: 10.1093/nar/gkp582. Epub 2009 Jul 13. Nucleic Acids Res. 2009. PMID: 19596811 Free PMC article.

2

Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration.

Leonetti C, Amodei S, D'Angelo C, Rizzo A, Benassi B, Antonelli A, Elli R, Stevens MF, D'Incalci M, Zupi G, Biroccio A. Leonetti C, et al. Among authors: zupi g. Mol Pharmacol. 2004 Nov;66(5):1138-46. doi: 10.1124/mol.104.001537. Epub 2004 Aug 10. Mol Pharmacol. 2004. PMID: 15304549

3

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.

Salvati E, Leonetti C, Rizzo A, Scarsella M, Mottolese M, Galati R, Sperduti I, Stevens MF, D'Incalci M, Blasco M, Chiorino G, Bauwens S, Horard B, Gilson E, Stoppacciaro A, Zupi G, Biroccio A. Salvati E, et al. Among authors: zupi g. J Clin Invest. 2007 Nov;117(11):3236-47. doi: 10.1172/JCI32461. J Clin Invest. 2007. PMID: 17932567 Free PMC article.

4

G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

Leonetti C, Scarsella M, Riggio G, Rizzo A, Salvati E, D'Incalci M, Staszewsky L, Frapolli R, Stevens MF, Stoppacciaro A, Mottolese M, Antoniani B, Gilson E, Zupi G, Biroccio A. Leonetti C, et al. Among authors: zupi g. Clin Cancer Res. 2008 Nov 15;14(22):7284-91. doi: 10.1158/1078-0432.CCR-08-0941. Clin Cancer Res. 2008. PMID: 19010844

5

DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents.

Biroccio A, Porru M, Rizzo A, Salvati E, D'Angelo C, Orlandi A, Passeri D, Franceschin M, Stevens MF, Gilson E, Beretta G, Zupi G, Pisano C, Zunino F, Leonetti C. Biroccio A, et al. Among authors: zupi g. Clin Cancer Res. 2011 Apr 15;17(8):2227-36. doi: 10.1158/1078-0432.CCR-10-3033. Epub 2011 Feb 25. Clin Cancer Res. 2011. PMID: 21355072

6

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy.

Salvati E, Scarsella M, Porru M, Rizzo A, Iachettini S, Tentori L, Graziani G, D'Incalci M, Stevens MF, Orlandi A, Passeri D, Gilson E, Zupi G, Leonetti C, Biroccio A. Salvati E, et al. Among authors: zupi g. Oncogene. 2010 Nov 25;29(47):6280-93. doi: 10.1038/onc.2010.344. Epub 2010 Aug 30. Oncogene. 2010. PMID: 20802516

7

Telomere dysfunction increases cisplatin and ecteinascidin-743 sensitivity of melanoma cells.

Biroccio A, Gabellini C, Amodei S, Benassi B, Del Bufalo D, Elli R, Antonelli A, D'Incalci M, Zupi G. Biroccio A, et al. Among authors: zupi g. Mol Pharmacol. 2003 Mar;63(3):632-8. doi: 10.1124/mol.63.3.632. Mol Pharmacol. 2003. PMID: 12606771

8

The future of antisense therapy: combination with anticancer treatments.

Biroccio A, Leonetti C, Zupi G. Biroccio A, et al. Among authors: zupi g. Oncogene. 2003 Sep 29;22(42):6579-88. doi: 10.1038/sj.onc.1206812. Oncogene. 2003. PMID: 14528283 Review.

9

TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells.

Biroccio A, Rizzo A, Elli R, Koering CE, Belleville A, Benassi B, Leonetti C, Stevens MF, D'Incalci M, Zupi G, Gilson E. Biroccio A, et al. Among authors: zupi g. Eur J Cancer. 2006 Aug;42(12):1881-8. doi: 10.1016/j.ejca.2006.03.010. Epub 2006 Jun 5. Eur J Cancer. 2006. PMID: 16750909

10

Targeting different signaling pathways with antisense oligonucleotides combination for cancer therapy.

Leonetti C, Zupi G. Leonetti C, et al. Among authors: zupi g. Curr Pharm Des. 2007;13(5):463-70. doi: 10.2174/138161207780162917. Curr Pharm Des. 2007. PMID: 17348843 Review.

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