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SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.
O'Rourke JG, Gareau JR, Ochaba J, Song W, Raskó T, Reverter D, Lee J, Monteys AM, Pallos J, Mee L, Vashishtha M, Apostol BL, Nicholson TP, Illes K, Zhu YZ, Dasso M, Bates GP, Difiglia M, Davidson B, Wanker EE, Marsh JL, Lima CD, Steffan JS, Thompson LM. O'Rourke JG, et al. Among authors: wanker ee. Cell Rep. 2013 Jul 25;4(2):362-75. doi: 10.1016/j.celrep.2013.06.034. Epub 2013 Jul 18. Cell Rep. 2013. PMID: 23871671 Free PMC article.
Polyglutamine expansion and Huntington's disease.
Bates GP, Mangiarini L, Wanker EE, Davies SW. Bates GP, et al. Among authors: wanker ee. Biochem Soc Trans. 1998 Aug;26(3):471-5. doi: 10.1042/bst0260471. Biochem Soc Trans. 1998. PMID: 9765898 Review. No abstract available.
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Eishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H. Fujita K, et al. Among authors: wanker ee. Nat Commun. 2013;4:1816. doi: 10.1038/ncomms2828. Nat Commun. 2013. PMID: 23652004 Free PMC article.
Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.
Kayatekin C, Matlack KE, Hesse WR, Guan Y, Chakrabortee S, Russ J, Wanker EE, Shah JV, Lindquist S. Kayatekin C, et al. Among authors: wanker ee. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12085-90. doi: 10.1073/pnas.1412504111. Epub 2014 Aug 4. Proc Natl Acad Sci U S A. 2014. PMID: 25092318 Free PMC article.
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski P, Lickfett S, Rybak-Wolf A, Menacho C, Le S, Pentimalli TM, Notopoulou S, Dykstra W, Oehler D, López-Calcerrada S, Mlody B, Otto M, Wu H, Richter Y, Roth P, Anand R, Kulka LAM, Meierhofer D, Glazar P, Legnini I, Telugu NS, Hahn T, Neuendorf N, Miller DC, Böddrich A, Polzin A, Mayatepek E, Diecke S, Olzscha H, Kirstein J, Ugalde C, Petrakis S, Cambridge S, Rajewsky N, Kühn R, Wanker EE, Priller J, Metzger JJ, Prigione A. Lisowski P, et al. Among authors: wanker ee. Nat Commun. 2024 Aug 22;15(1):7027. doi: 10.1038/s41467-024-51216-w. Nat Commun. 2024. PMID: 39174523 Free PMC article.
188 results