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Page 1
Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor.
Ando M, Sato N, Nagase T, Nagai K, Ishikawa S, Takahashi H, Ohtake N, Ito J, Hirayama M, Mitobe Y, Iwaasa H, Gomori A, Matsushita H, Tadano K, Fujino N, Tanaka S, Ohe T, Ishihara A, Kanatani A, Fukami T. Ando M, et al. Among authors: ohtake n. Bioorg Med Chem. 2009 Aug 15;17(16):6106-22. doi: 10.1016/j.bmc.2009.05.069. Epub 2009 Jun 2. Bioorg Med Chem. 2009. PMID: 19616955
Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives.
Ogino Y, Ohtake N, Nagae Y, Matsuda K, Moriya M, Suga T, Ishikawa M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, Fukami T. Ogino Y, et al. Among authors: ohtake n. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5010-4. doi: 10.1016/j.bmcl.2008.08.018. Epub 2008 Aug 12. Bioorg Med Chem Lett. 2008. PMID: 18723347
Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists.
Ogino Y, Ohtake N, Nagae Y, Matsuda K, Ishikawa M, Moriya M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, Fukami T. Ogino Y, et al. Among authors: ohtake n. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4997-5001. doi: 10.1016/j.bmcl.2008.08.021. Epub 2008 Aug 13. Bioorg Med Chem Lett. 2008. PMID: 18752943
Structure-activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines.
Takahashi H, Ohtake N, Sakamoto T, Iino T, Kawanishi N, Nakamura M, Yoshizumi T, Niiyama K, Ozaki S, Okada H, Kano A, Takahashi H, Ishii Y, Okada M, Saito M, Sawazaki Y, Hayama T, Nishikibe M. Takahashi H, et al. Among authors: ohtake n. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1503-7. doi: 10.1016/j.bmcl.2004.01.008. Bioorg Med Chem Lett. 2004. PMID: 15006391
Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.
Ito M, Ishihara A, Gomori A, Egashira S, Matsushita H, Mashiko S, Ito J, Ito M, Nakase K, Haga Y, Iwaasa H, Suzuki T, Ohtake N, Moriya M, Sato N, MacNeil DJ, Takenaga N, Tokita S, Kanatani A. Ito M, et al. Among authors: ohtake n. Eur J Pharmacol. 2009 Dec 10;624(1-3):77-83. doi: 10.1016/j.ejphar.2009.10.004. Epub 2009 Oct 18. Eur J Pharmacol. 2009. PMID: 19836369
206 results