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Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels.
Husain SS, Nirthanan S, Ruesch D, Solt K, Cheng Q, Li GD, Arevalo E, Olsen RW, Raines DE, Forman SA, Cohen JB, Miller KW. Husain SS, et al. Among authors: miller kw. J Med Chem. 2006 Aug 10;49(16):4818-25. doi: 10.1021/jm051207b. J Med Chem. 2006. PMID: 16884293
p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.
Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KW. Husain SS, et al. Among authors: miller kw. J Med Chem. 2010 Sep 9;53(17):6432-44. doi: 10.1021/jm100498u. J Med Chem. 2010. PMID: 20704351 Free PMC article.
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[No authors listed] [No authors listed] PMID: 33370831
300 results