Kanatani A - Search Results

1

Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists.

Ando M, Sekino E, Haga Y, Moriya M, Ito M, Ito J, Iwaasa H, Ishihara A, Kanatani A, Ohtake N. Ando M, et al. Among authors: kanatani a. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5186-90. doi: 10.1016/j.bmcl.2009.07.023. Epub 2009 Jul 9. Bioorg Med Chem Lett. 2009. PMID: 19632840

2

Design and synthesis of the potent, orally available, brain-penetrable arylpyrazole class of neuropeptide Y5 receptor antagonists.

Sato N, Takahashi T, Shibata T, Haga Y, Sakuraba A, Hirose M, Sato M, Nonoshita K, Koike Y, Kitazawa H, Fujino N, Ishii Y, Ishihara A, Kanatani A, Fukami T. Sato N, et al. Among authors: kanatani a. J Med Chem. 2003 Feb 27;46(5):666-9. doi: 10.1021/jm025513q. J Med Chem. 2003. PMID: 12593644

3

N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist.

Hirose M, Egashira S, Goto Y, Hashihayata T, Ohtake N, Iwaasa H, Hata M, Fukami T, Kanatani A, Yamada K. Hirose M, et al. Among authors: kanatani a. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4497-9. doi: 10.1016/j.bmcl.2003.08.038. Bioorg Med Chem Lett. 2003. PMID: 14643355

4

Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists.

Sato N, Shibata T, Jitsuoka M, Ohno T, Takahashi T, Hirohashi T, Kanno T, Iwaasa H, Kanatani A, Fukami T. Sato N, et al. Among authors: kanatani a. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1761-4. doi: 10.1016/j.bmcl.2004.01.049. Bioorg Med Chem Lett. 2004. PMID: 15026066

5

Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice.

Mashiko S, Ishihara A, Gomori A, Moriya R, Ito M, Iwaasa H, Matsuda M, Feng Y, Shen Z, Marsh DJ, Bednarek MA, MacNeil DJ, Kanatani A. Mashiko S, et al. Among authors: kanatani a. Endocrinology. 2005 Jul;146(7):3080-6. doi: 10.1210/en.2004-1150. Epub 2005 Apr 7. Endocrinology. 2005. PMID: 15817671

6

Novel potent neuropeptide Y Y5 receptor antagonists: synthesis and structure-activity relationships of phenylpiperazine derivatives.

Takahashi T, Sakuraba A, Hirohashi T, Shibata T, Hirose M, Haga Y, Nonoshita K, Kanno T, Ito J, Iwaasa H, Kanatani A, Fukami T, Sato N. Takahashi T, et al. Among authors: kanatani a. Bioorg Med Chem. 2006 Nov 15;14(22):7501-11. doi: 10.1016/j.bmc.2006.07.023. Epub 2006 Aug 17. Bioorg Med Chem. 2006. PMID: 16919461

7

(9S)-9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a selective and orally active neuropeptide Y Y5 receptor antagonist.

Sato N, Jitsuoka M, Shibata T, Hirohashi T, Nonoshita K, Moriya M, Haga Y, Sakuraba A, Ando M, Ohe T, Iwaasa H, Gomori A, Ishihara A, Kanatani A, Fukami T. Sato N, et al. Among authors: kanatani a. J Med Chem. 2008 Aug 14;51(15):4765-70. doi: 10.1021/jm8003587. Epub 2008 Jul 19. J Med Chem. 2008. PMID: 18637668

8

Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives.

Ogino Y, Ohtake N, Nagae Y, Matsuda K, Moriya M, Suga T, Ishikawa M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, Fukami T. Ogino Y, et al. Among authors: kanatani a. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5010-4. doi: 10.1016/j.bmcl.2008.08.018. Epub 2008 Aug 12. Bioorg Med Chem Lett. 2008. PMID: 18723347

9

Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists.

Ogino Y, Ohtake N, Nagae Y, Matsuda K, Ishikawa M, Moriya M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, Fukami T. Ogino Y, et al. Among authors: kanatani a. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4997-5001. doi: 10.1016/j.bmcl.2008.08.021. Epub 2008 Aug 13. Bioorg Med Chem Lett. 2008. PMID: 18752943

10

Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists.

Sato N, Jitsuoka M, Ishikawa S, Nagai K, Tsuge H, Ando M, Okamoto O, Iwaasa H, Gomori A, Ishihara A, Kanatani A, Fukami T. Sato N, et al. Among authors: kanatani a. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1670-4. doi: 10.1016/j.bmcl.2009.01.101. Epub 2009 Feb 4. Bioorg Med Chem Lett. 2009. PMID: 19233647

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