Gerhartz B - Search Results

1

Backbone 1H, 13C, and 15N resonance assignments for the 26-kD human de-ubiquitinating enzyme UCH-L3.

Harris R, Eidhoff U, Vinzenz D, Renatus M, Gerhartz B, Hommel U, Driscoll PC. Harris R, et al. Among authors: gerhartz b. Biomol NMR Assign. 2007 Jul;1(1):51-3. doi: 10.1007/s12104-007-9012-5. Epub 2007 May 11. Biomol NMR Assign. 2007. PMID: 19636824

2

Structural basis of ubiquitin recognition by the deubiquitinating protease USP2.

Renatus M, Parrado SG, D'Arcy A, Eidhoff U, Gerhartz B, Hassiepen U, Pierrat B, Riedl R, Vinzenz D, Worpenberg S, Kroemer M. Renatus M, et al. Among authors: gerhartz b. Structure. 2006 Aug;14(8):1293-302. doi: 10.1016/j.str.2006.06.012. Structure. 2006. PMID: 16905103 Free PMC article.

3

Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2.

Tirat A, Schilb A, Riou V, Leder L, Gerhartz B, Zimmermann J, Worpenberg S, Eidhoff U, Freuler F, Stettler T, Mayr L, Ottl J, Leuenberger B, Filipuzzi I. Tirat A, et al. Among authors: gerhartz b. Anal Biochem. 2005 Aug 15;343(2):244-55. doi: 10.1016/j.ab.2005.04.023. Anal Biochem. 2005. PMID: 15963938

4

Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.

Ostermann N, Eder J, Eidhoff U, Zink F, Hassiepen U, Worpenberg S, Maibaum J, Simic O, Hommel U, Gerhartz B. Ostermann N, et al. Among authors: gerhartz b. J Mol Biol. 2006 Jan 13;355(2):249-61. doi: 10.1016/j.jmb.2005.10.027. Epub 2005 Nov 8. J Mol Biol. 2006. PMID: 16305800

5

Aspartic proteases in drug discovery.

Eder J, Hommel U, Cumin F, Martoglio B, Gerhartz B. Eder J, et al. Among authors: gerhartz b. Curr Pharm Des. 2007;13(3):271-85. doi: 10.2174/138161207779313560. Curr Pharm Des. 2007. PMID: 17313361 Review.

6

Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.

Mac Sweeney A, Gil-Parrado S, Vinzenz D, Bernardi A, Hein A, Bodendorf U, Erbel P, Logel C, Gerhartz B. Mac Sweeney A, et al. Among authors: gerhartz b. J Mol Biol. 2008 Dec 5;384(1):228-39. doi: 10.1016/j.jmb.2008.09.029. Epub 2008 Sep 19. J Mol Biol. 2008. PMID: 18824173

7

Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.

Vulpetti A, Randl S, Rüdisser S, Ostermann N, Erbel P, Mac Sweeney A, Zoller T, Salem B, Gerhartz B, Cumin F, Hommel U, Dalvit C, Lorthiois E, Maibaum J. Vulpetti A, et al. Among authors: gerhartz b. J Med Chem. 2017 Mar 9;60(5):1946-1958. doi: 10.1021/acs.jmedchem.6b01684. Epub 2017 Feb 20. J Med Chem. 2017. PMID: 28157311

8

Small-molecule factor D inhibitors targeting the alternative complement pathway.

Maibaum J, Liao SM, Vulpetti A, Ostermann N, Randl S, Rüdisser S, Lorthiois E, Erbel P, Kinzel B, Kolb FA, Barbieri S, Wagner J, Durand C, Fettis K, Dussauge S, Hughes N, Delgado O, Hommel U, Gould T, Mac Sweeney A, Gerhartz B, Cumin F, Flohr S, Schubart A, Jaffee B, Harrison R, Risitano AM, Eder J, Anderson K. Maibaum J, et al. Among authors: gerhartz b. Nat Chem Biol. 2016 Dec;12(12):1105-1110. doi: 10.1038/nchembio.2208. Epub 2016 Oct 24. Nat Chem Biol. 2016. PMID: 27775713

9

Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization.

Fernández-Montalván A, Bouwmeester T, Joberty G, Mader R, Mahnke M, Pierrat B, Schlaeppi JM, Worpenberg S, Gerhartz B. Fernández-Montalván A, et al. Among authors: gerhartz b. FEBS J. 2007 Aug;274(16):4256-70. doi: 10.1111/j.1742-4658.2007.05952.x. Epub 2007 Jul 25. FEBS J. 2007. PMID: 17651432 Free article.

10

Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV.

Namoto K, Sirockin F, Ostermann N, Gessier F, Flohr S, Sedrani R, Gerhartz B, Trappe J, Hassiepen U, Duttaroy A, Ferreira S, Sutton JM, Clark DE, Fenton G, Beswick M, Baeschlin DK. Namoto K, et al. Among authors: gerhartz b. Bioorg Med Chem Lett. 2014 Feb 1;24(3):731-6. doi: 10.1016/j.bmcl.2013.12.118. Epub 2014 Jan 6. Bioorg Med Chem Lett. 2014. PMID: 24439847

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