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Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell-dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccination.
de Alencar BC, Persechini PM, Haolla FA, de Oliveira G, Silverio JC, Lannes-Vieira J, Machado AV, Gazzinelli RT, Bruna-Romero O, Rodrigues MM. de Alencar BC, et al. Among authors: de oliveira g. Infect Immun. 2009 Oct;77(10):4383-95. doi: 10.1128/IAI.01459-08. Epub 2009 Aug 3. Infect Immun. 2009. PMID: 19651871 Free PMC article.
Heterologous plasmid DNA prime-recombinant human adenovirus 5 boost vaccination generates a stable pool of protective long-lived CD8(+) T effector memory cells specific for a human parasite, Trypanosoma cruzi.
Rigato PO, de Alencar BC, de Vasconcelos JR, Dominguez MR, Araújo AF, Machado AV, Gazzinelli RT, Bruna-Romero O, Rodrigues MM. Rigato PO, et al. Among authors: de alencar bc. Infect Immun. 2011 May;79(5):2120-30. doi: 10.1128/IAI.01190-10. Epub 2011 Feb 28. Infect Immun. 2011. PMID: 21357719 Free PMC article.
CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2.
Araújo AF, de Alencar BC, Vasconcelos JR, Hiyane MI, Marinho CR, Penido ML, Boscardin SB, Hoft DF, Gazzinelli RT, Rodrigues MM. Araújo AF, et al. Among authors: de alencar bc. Infect Immun. 2005 Sep;73(9):6017-25. doi: 10.1128/IAI.73.9.6017-6025.2005. Infect Immun. 2005. PMID: 16113322 Free PMC article.
Strain-specific protective immunity following vaccination against experimental Trypanosoma cruzi infection.
Haolla FA, Claser C, de Alencar BC, Tzelepis F, de Vasconcelos JR, de Oliveira G, Silvério JC, Machado AV, Lannes-Vieira J, Bruna-Romero O, Gazzinelli RT, dos Santos RR, Soares MB, Rodrigues MM. Haolla FA, et al. Among authors: de oliveira g, de vasconcelos jr, de alencar bc. Vaccine. 2009 Sep 18;27(41):5644-53. doi: 10.1016/j.vaccine.2009.07.013. Epub 2009 Jul 25. Vaccine. 2009. PMID: 19635607 Free article.
Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany a suboptimal CD8+ T-cell response: reversal by adenoviral vaccine.
Vasconcelos JR, Bruña-Romero O, Araújo AF, Dominguez MR, Ersching J, de Alencar BC, Machado AV, Gazzinelli RT, Bortoluci KR, Amarante-Mendes GP, Lopes MF, Rodrigues MM. Vasconcelos JR, et al. Among authors: de alencar bc. PLoS Pathog. 2012;8(5):e1002699. doi: 10.1371/journal.ppat.1002699. Epub 2012 May 17. PLoS Pathog. 2012. PMID: 22615561 Free PMC article.
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