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Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) exert their anti-proliferative activity by interfering with Akt-mTOR signaling and bax:bcl-2 ratio modulation in cells from chronic myeloid leukemic patients.
Di Stefano C, Marfe G, Trawinska MM, Sinibaldi-Salimei P, Silvestri R, Amadori S, Abruzzese E. Di Stefano C, et al. Cancer Sci. 2010 Apr;101(4):991-1000. doi: 10.1111/j.1349-7006.2010.01490.x. Cancer Sci. 2010. Retraction in: Cancer Sci. 2025 Jan;116(1):277. doi: 10.1111/cas.16390 PMID: 20704577 Free PMC article. Retracted.
Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells.
Marfe G, Di Stefano C, Gambacurta A, Ottone T, Martini V, Abruzzese E, Mologni L, Sinibaldi-Salimei P, de Fabritis P, Gambacorti-Passerini C, Amadori S, Birge RB. Marfe G, et al. Among authors: di stefano c. Exp Hematol. 2011 Jun;39(6):653-665.e6. doi: 10.1016/j.exphem.2011.02.013. Epub 2011 Mar 8. Exp Hematol. 2011. PMID: 21392556 Free article.
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant.
Silvestri R, Marfè G, Artico M, La Regina G, Lavecchia A, Novellino E, Morgante E, Di Stefano C, Catalano G, Filomeni G, Abruzzese E, Ciriolo MR, Russo MA, Amadori S, Cirilli R, La Torre F, Sinibaldi Salimei P. Silvestri R, et al. Among authors: di stefano c. J Med Chem. 2006 Sep 21;49(19):5840-4. doi: 10.1021/jm0602716. J Med Chem. 2006. PMID: 16970408 Free article.
PYRROLO[1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) induce apoptosis in K562 cells.
Marfe G, Di Stefano C, Silvestri R, Abruzzese E, Catalano G, Di Renzo L, Filomeni G, Giorda E, La Regina G, Morgante E, Ciriolo MR, Russo MA, Amadori S, Sinibaldi-Salimei P. Marfe G, et al. Among authors: di stefano c, di renzo l. BMC Cancer. 2007 Nov 9;7:207. doi: 10.1186/1471-2407-7-207. BMC Cancer. 2007. PMID: 17996085 Free PMC article.
225 results