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E6201 [(3S,4R,5Z,8S,9S,11E)-14-(ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-1 and MEK kinase-1: in vitro characterization of its anti-inflammatory and antihyperproliferative activities.
Goto M, Chow J, Muramoto K, Chiba K, Yamamoto S, Fujita M, Obaishi H, Tai K, Mizui Y, Tanaka I, Young D, Yang H, Wang YJ, Shirota H, Gusovsky F. Goto M, et al. Among authors: young d. J Pharmacol Exp Ther. 2009 Nov;331(2):485-95. doi: 10.1124/jpet.109.156554. Epub 2009 Aug 14. J Pharmacol Exp Ther. 2009. PMID: 19684251
A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity.
Hawkins LD, Ishizaka ST, McGuinness P, Zhang H, Gavin W, DeCosta B, Meng Z, Yang H, Mullarkey M, Young DW, Yang H, Rossignol DP, Nault A, Rose J, Przetak M, Chow JC, Gusovsky F. Hawkins LD, et al. Among authors: young dw. J Pharmacol Exp Ther. 2002 Feb;300(2):655-61. doi: 10.1124/jpet.300.2.655. J Pharmacol Exp Ther. 2002. PMID: 11805229 Clinical Trial.
The extra domain A of fibronectin activates Toll-like receptor 4.
Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, Rose J, Chow JC, Strauss JF 3rd. Okamura Y, et al. Among authors: young dw. J Biol Chem. 2001 Mar 30;276(13):10229-33. doi: 10.1074/jbc.M100099200. Epub 2001 Jan 9. J Biol Chem. 2001. PMID: 11150311 Free article.
Emissions of HFC-23 do not reflect commitments made under the Kigali Amendment.
Adam B, Western LM, Mühle J, Choi H, Krummel PB, O'Doherty S, Young D, Stanley KM, Fraser PJ, Harth CM, Salameh PK, Weiss RF, Prinn RG, Kim J, Park H, Park S, Rigby M. Adam B, et al. Among authors: young d. Commun Earth Environ. 2024;5(1):783. doi: 10.1038/s43247-024-01946-y. Epub 2024 Dec 21. Commun Earth Environ. 2024. PMID: 39717369 Free PMC article.
5,412 results