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Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability.
Seehaus S, Shahzad K, Kashif M, Vinnikov IA, Schiller M, Wang H, Madhusudhan T, Eckstein V, Bierhaus A, Bea F, Blessing E, Weiler H, Frommhold D, Nawroth PP, Isermann B. Seehaus S, et al. Among authors: madhusudhan t. Circulation. 2009 Sep 1;120(9):774-84. doi: 10.1161/CIRCULATIONAHA.109.849539. Epub 2009 Aug 17. Circulation. 2009. PMID: 19687358
At the cutting edge: conformational PARtiality.
Madhusudhan T, Isermann B. Madhusudhan T, et al. J Thromb Haemost. 2012 Aug;10(8):1672-4. doi: 10.1111/j.1538-7836.2012.04832.x. J Thromb Haemost. 2012. PMID: 22742620 Free article. No abstract available.
Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy.
Wang H, Madhusudhan T, He T, Hummel B, Schmidt S, Vinnikov IA, Shahzad K, Kashif M, Muller-Krebs S, Schwenger V, Bierhaus A, Rudofsky G, Nawroth PP, Isermann B. Wang H, et al. Among authors: madhusudhan t. Blood. 2011 May 12;117(19):5231-42. doi: 10.1182/blood-2010-10-314773. Epub 2011 Mar 9. Blood. 2011. PMID: 21389321 Free article.
Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation.
Kashif M, Hellwig A, Hashemolhosseini S, Kumar V, Bock F, Wang H, Shahzad K, Ranjan S, Wolter J, Madhusudhan T, Bierhaus A, Nawroth P, Isermann B. Kashif M, et al. Among authors: madhusudhan t. J Biol Chem. 2012 Feb 17;287(8):5400-11. doi: 10.1074/jbc.M111.289801. Epub 2011 Dec 15. J Biol Chem. 2012. PMID: 22174410 Free PMC article.
Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc.
Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, Pelicci PG, Kashif M, Ranjan S, Schmidt S, Ritzel R, Schwenger V, Reymann KG, Esmon CT, Madhusudhan T, Nawroth PP, Isermann B. Bock F, et al. Among authors: madhusudhan t. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):648-53. doi: 10.1073/pnas.1218667110. Epub 2012 Dec 24. Proc Natl Acad Sci U S A. 2013. PMID: 23267072 Free PMC article.
Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy.
Shahzad K, Bock F, Al-Dabet MM, Gadi I, Kohli S, Nazir S, Ghosh S, Ranjan S, Wang H, Madhusudhan T, Nawroth PP, Isermann B. Shahzad K, et al. Among authors: madhusudhan t. J Am Soc Nephrol. 2016 Aug;27(8):2270-5. doi: 10.1681/ASN.2015060676. Epub 2016 Feb 1. J Am Soc Nephrol. 2016. PMID: 26832955 Free PMC article.
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.
Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B. Madhusudhan T, et al. Blood. 2017 Sep 21;130(12):1445-1455. doi: 10.1182/blood-2017-02-767921. Epub 2017 Jul 7. Blood. 2017. PMID: 28687614 Free PMC article.
46 results