Johns TG - Search Results

1

Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.

Lu KV, Zhu S, Cvrljevic A, Huang TT, Sarkaria S, Ahkavan D, Dang J, Dinca EB, Plaisier SB, Oderberg I, Lee Y, Chen Z, Caldwell JS, Xie Y, Loo JA, Seligson D, Chakravari A, Lee FY, Weinmann R, Cloughesy TF, Nelson SF, Bergers G, Graeber T, Furnari FB, James CD, Cavenee WK, Johns TG, Mischel PS. Lu KV, et al. Among authors: johns tg. Cancer Res. 2009 Sep 1;69(17):6889-98. doi: 10.1158/0008-5472.CAN-09-0347. Epub 2009 Aug 18. Cancer Res. 2009. PMID: 19690143 Free PMC article.

2

Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor.

Mishima K, Johns TG, Luwor RB, Scott AM, Stockert E, Jungbluth AA, Ji XD, Suvarna P, Voland JR, Old LJ, Huang HJ, Cavenee WK. Mishima K, et al. Among authors: johns tg. Cancer Res. 2001 Jul 15;61(14):5349-54. Cancer Res. 2001. PMID: 11454673

3

Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR.

Luwor RB, Johns TG, Murone C, Huang HJ, Cavenee WK, Ritter G, Old LJ, Burgess AW, Scott AM. Luwor RB, et al. Among authors: johns tg. Cancer Res. 2001 Jul 15;61(14):5355-61. Cancer Res. 2001. PMID: 11454674

4

Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene.

Johns TG, Stockert E, Ritter G, Jungbluth AA, Huang HJ, Cavenee WK, Smyth FE, Hall CM, Watson N, Nice EC, Gullick WJ, Old LJ, Burgess AW, Scott AM. Johns TG, et al. Int J Cancer. 2002 Mar 20;98(3):398-408. doi: 10.1002/ijc.10189. Int J Cancer. 2002. PMID: 11920591

5

Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity.

Perera RM, Narita Y, Furnari FB, Gan HK, Murone C, Ahlkvist M, Luwor RB, Burgess AW, Stockert E, Jungbluth AA, Old LJ, Cavenee WK, Scott AM, Johns TG. Perera RM, et al. Among authors: johns tg. Clin Cancer Res. 2005 Sep 1;11(17):6390-9. doi: 10.1158/1078-0432.CCR-04-2653. Clin Cancer Res. 2005. PMID: 16144944

6

Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478.

Lee FT, Mountain AJ, Kelly MP, Hall C, Rigopoulos A, Johns TG, Smyth FE, Brechbiel MW, Nice EC, Burgess AW, Scott AM. Lee FT, et al. Among authors: johns tg. Clin Cancer Res. 2005 Oct 1;11(19 Pt 2):7080s-7086s. doi: 10.1158/1078-0432.CCR-1004-0019. Clin Cancer Res. 2005. PMID: 16203806

7

The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization.

Johns TG, Perera RM, Vernes SC, Vitali AA, Cao DX, Cavenee WK, Scott AM, Furnari FB. Johns TG, et al. Clin Cancer Res. 2007 Mar 15;13(6):1911-25. doi: 10.1158/1078-0432.CCR-06-1453. Clin Cancer Res. 2007. PMID: 17363548 Free article.

8

MAb 806 enhances the efficacy of ionizing radiation in glioma xenografts expressing the de2-7 epidermal growth factor receptor.

Johns TG, McKay MJ, Cvrljevic AN, Gan HK, Taylor C, Xu H, Smyth FE, Scott AM. Johns TG, et al. Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):572-8. doi: 10.1016/j.ijrobp.2010.03.027. Epub 2010 Jul 16. Int J Radiat Oncol Biol Phys. 2010. PMID: 20638193

9

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma.

Inda MM, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, Brennan C, Johns TG, Bachoo R, Hadwiger P, Tan P, Depinho RA, Cavenee W, Furnari F. Inda MM, et al. Among authors: johns tg. Genes Dev. 2010 Aug 15;24(16):1731-45. doi: 10.1101/gad.1890510. Genes Dev. 2010. PMID: 20713517 Free PMC article.

10

Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism.

Cvrljevic AN, Akhavan D, Wu M, Martinello P, Furnari FB, Johnston AJ, Guo D, Pike L, Cavenee WK, Scott AM, Mischel PS, Hoogenraad NJ, Johns TG. Cvrljevic AN, et al. Among authors: johns tg. J Cell Sci. 2011 Sep 1;124(Pt 17):2938-50. doi: 10.1242/jcs.083295. J Cell Sci. 2011. PMID: 21878501 Free PMC article.

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