Lavé T - Search Results

1

In vivo and in vitro characterization of ethyl methanesulfonate pharmacokinetics in animals and in human.

Lavé T, Birnböck H, Götschi A, Ramp T, Pähler A. Lavé T, et al. Toxicol Lett. 2009 Nov 12;190(3):303-9. doi: 10.1016/j.toxlet.2009.07.030. Epub 2009 Aug 18. Toxicol Lett. 2009. PMID: 19695315

2

Modelling of patient EMS exposure: translating pharmacokinetics of EMS in vitro and in animals into patients.

Lavé T, Paehler A, Grimm HP, Gocke E, Müller L. Lavé T, et al. Toxicol Lett. 2009 Nov 12;190(3):310-6. doi: 10.1016/j.toxlet.2009.07.031. Epub 2009 Aug 18. Toxicol Lett. 2009. PMID: 19695316

3

Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.

Müller L, Gocke E, Lavé T, Pfister T. Müller L, et al. Among authors: lave t. Toxicol Lett. 2009 Nov 12;190(3):317-29. doi: 10.1016/j.toxlet.2009.04.003. Epub 2009 Apr 10. Toxicol Lett. 2009. PMID: 19443141

Detailed absorption, distribution and metabolism studies in mice, rats and monkeys and with human surrogates in vitro enable us to estimate the safety factors also for the calculated likely highest exposure (AUC and C(max)) of patients to EMS [Lave, T., Birnbock, H. …

Detailed absorption, distribution and metabolism studies in mice, rats and monkeys and with human surrogates in vitro enable us to estimate …

4

Human clearance prediction: shifting the paradigm.

Lavé T, Chapman K, Goldsmith P, Rowland M. Lavé T, et al. Expert Opin Drug Metab Toxicol. 2009 Sep;5(9):1039-48. doi: 10.1517/17425250903099649. Expert Opin Drug Metab Toxicol. 2009. PMID: 19611405 Review.

5

Animal pharmacokinetics and interspecies scaling from animals to man of lamifiban, a new platelet aggregation inhibitor.

Lave T, Saner A, Coassolo P, Brandt R, Schmitt-Hoffmann AH, Chou RC. Lave T, et al. J Pharm Pharmacol. 1996 Jun;48(6):573-7. doi: 10.1111/j.2042-7158.1996.tb05976.x. J Pharm Pharmacol. 1996. PMID: 8832489

6

A novel strategy for physiologically based predictions of human pharmacokinetics.

Jones HM, Parrott N, Jorga K, Lavé T. Jones HM, et al. Among authors: lave t. Clin Pharmacokinet. 2006;45(5):511-42. doi: 10.2165/00003088-200645050-00006. Clin Pharmacokinet. 2006. PMID: 16640456

7

Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man.

Parrott N, Jones H, Paquereau N, Lavé T. Parrott N, et al. Among authors: lave t. Basic Clin Pharmacol Toxicol. 2005 Mar;96(3):193-9. doi: 10.1111/j.1742-7843.2005.pto960308.x. Basic Clin Pharmacol Toxicol. 2005. PMID: 15733214 Free article.

8

Animal pharmacokinetics and interspecies scaling of Ro 25-6833 and related (lactamylvinyl)cephalosporins.

Richter WF, Heizmann P, Meyer J, Starke V, Lave T. Richter WF, et al. Among authors: lave t. J Pharm Sci. 1998 Apr;87(4):496-500. doi: 10.1021/js970261f. J Pharm Sci. 1998. PMID: 9548904

9

Prediction of human pharmacokinetics based on preclinical in vitro and in vivo data.

Lavé T, Luttringer O, Zuegge J, Schneider G, Coassolo P, Theil FP. Lavé T, et al. Ernst Schering Res Found Workshop. 2002;(37):81-104. doi: 10.1007/978-3-662-04383-7_5. Ernst Schering Res Found Workshop. 2002. PMID: 11975202 Review. No abstract available.

10

Interspecies pharmacokinetic comparisons and allometric scaling of napsagatran, a low molecular weight thrombin inhibitor.

Lavé T, Portmann R, Schenker G, Gianni A, Guenzi A, Girometta MA, Schmitt M. Lavé T, et al. J Pharm Pharmacol. 1999 Jan;51(1):85-91. doi: 10.1211/0022357991772006. J Pharm Pharmacol. 1999. PMID: 10197423

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