Stehle T - Search Results

1

The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria.

Metzger U, Schall C, Zocher G, Unsöld I, Stec E, Li SM, Heide L, Stehle T. Metzger U, et al. Among authors: stehle t. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14309-14. doi: 10.1073/pnas.0904897106. Epub 2009 Aug 12. Proc Natl Acad Sci U S A. 2009. PMID: 19706516 Free PMC article.

2

Site-directed mutagenesis switching a dimethylallyl tryptophan synthase to a specific tyrosine C3-prenylating enzyme.

Fan A, Zocher G, Stec E, Stehle T, Li SM. Fan A, et al. Among authors: stehle t. J Biol Chem. 2015 Jan 16;290(3):1364-73. doi: 10.1074/jbc.M114.623413. Epub 2014 Dec 4. J Biol Chem. 2015. PMID: 25477507 Free PMC article.

3

Structure-function analysis of an enzymatic prenyl transfer reaction identifies a reaction chamber with modifiable specificity.

Jost M, Zocher G, Tarcz S, Matuschek M, Xie X, Li SM, Stehle T. Jost M, et al. Among authors: stehle t. J Am Chem Soc. 2010 Dec 22;132(50):17849-58. doi: 10.1021/ja106817c. Epub 2010 Nov 24. J Am Chem Soc. 2010. PMID: 21105662

4

Structure and catalytic mechanism of a cyclic dipeptide prenyltransferase with broad substrate promiscuity.

Schuller JM, Zocher G, Liebhold M, Xie X, Stahl M, Li SM, Stehle T. Schuller JM, et al. Among authors: stehle t. J Mol Biol. 2012 Sep 7;422(1):87-99. doi: 10.1016/j.jmb.2012.05.033. Epub 2012 Jun 6. J Mol Biol. 2012. PMID: 22683356

5

Structure-based engineering increased the catalytic turnover rate of a novel phenazine prenyltransferase.

Zocher G, Saleh O, Heim JB, Herbst DA, Heide L, Stehle T. Zocher G, et al. Among authors: stehle t. PLoS One. 2012;7(10):e48427. doi: 10.1371/journal.pone.0048427. Epub 2012 Oct 31. PLoS One. 2012. PMID: 23119011 Free PMC article.

6

Structural basis of the interaction of MbtH-like proteins, putative regulators of nonribosomal peptide biosynthesis, with adenylating enzymes.

Herbst DA, Boll B, Zocher G, Stehle T, Heide L. Herbst DA, et al. Among authors: stehle t. J Biol Chem. 2013 Jan 18;288(3):1991-2003. doi: 10.1074/jbc.M112.420182. Epub 2012 Nov 28. J Biol Chem. 2013. PMID: 23192349 Free PMC article.

7

Catalytic mechanism of stereospecific formation of cis-configured prenylated pyrroloindoline diketopiperazines by indole prenyltransferases.

Yu X, Zocher G, Xie X, Liebhold M, Schütz S, Stehle T, Li SM. Yu X, et al. Among authors: stehle t. Chem Biol. 2013 Dec 19;20(12):1492-501. doi: 10.1016/j.chembiol.2013.10.007. Epub 2013 Nov 14. Chem Biol. 2013. PMID: 24239009

8

Structure-based protein engineering enables prenyl donor switching of a fungal aromatic prenyltransferase.

Mai P, Zocher G, Stehle T, Li SM. Mai P, et al. Among authors: stehle t. Org Biomol Chem. 2018 Oct 17;16(40):7461-7469. doi: 10.1039/c8ob02037j. Org Biomol Chem. 2018. PMID: 30270371

9

Complete Decoration of the Indolyl Residue in cyclo-l-Trp-l-Trp with Geranyl Moieties by Using Engineered Dimethylallyl Transferases.

Liao G, Mai P, Fan J, Zocher G, Stehle T, Li SM. Liao G, et al. Among authors: stehle t. Org Lett. 2018 Nov 16;20(22):7201-7205. doi: 10.1021/acs.orglett.8b03124. Epub 2018 Oct 31. Org Lett. 2018. PMID: 30378433

10

Reprogramming Substrate and Catalytic Promiscuity of Tryptophan Prenyltransferases.

Ostertag E, Zheng L, Broger K, Stehle T, Li SM, Zocher G. Ostertag E, et al. Among authors: stehle t. J Mol Biol. 2021 Jan 22;433(2):166726. doi: 10.1016/j.jmb.2020.11.025. Epub 2020 Nov 26. J Mol Biol. 2021. PMID: 33249189

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