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The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers.
Kodach LL, Wiercinska E, de Miranda NF, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, van Noesel CJ, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJ, Hardwick JC. Kodach LL, et al. Among authors: van noesel cj, van den brink gr. Gastroenterology. 2008 May;134(5):1332-41. doi: 10.1053/j.gastro.2008.02.059. Epub 2008 Mar 4. Gastroenterology. 2008. PMID: 18471510
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.
De Sousa E Melo F, Wang X, Jansen M, Fessler E, Trinh A, de Rooij LP, de Jong JH, de Boer OJ, van Leersum R, Bijlsma MF, Rodermond H, van der Heijden M, van Noesel CJ, Tuynman JB, Dekker E, Markowetz F, Medema JP, Vermeulen L. De Sousa E Melo F, et al. Among authors: van der heijden m, van noesel cj, van leersum r. Nat Med. 2013 May;19(5):614-8. doi: 10.1038/nm.3174. Epub 2013 Apr 14. Nat Med. 2013. PMID: 23584090
The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC.
Voorneveld PW, Kodach LL, Jacobs RJ, van Noesel CJ, Peppelenbosch MP, Korkmaz KS, Molendijk I, Dekker E, Morreau H, van Pelt GW, Tollenaar RA, Mesker W, Hawinkels LJ, Paauwe M, Verspaget HW, Geraets DT, Hommes DW, Offerhaus GJ, van den Brink GR, Ten Dijke P, Hardwick JC. Voorneveld PW, et al. Among authors: van pelt gw, van noesel cj, van den brink gr. Br J Cancer. 2015 Jan 6;112(1):122-30. doi: 10.1038/bjc.2014.560. Epub 2014 Nov 13. Br J Cancer. 2015. PMID: 25393365 Free PMC article.
A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype.
Fessler E, Jansen M, De Sousa E Melo F, Zhao L, Prasetyanti PR, Rodermond H, Kandimalla R, Linnekamp JF, Franitza M, van Hooff SR, de Jong JH, Oppeneer SC, van Noesel CJ, Dekker E, Stassi G, Wang X, Medema JP, Vermeulen L. Fessler E, et al. Among authors: van noesel cj, van hooff sr. Oncogene. 2016 Nov 17;35(46):6026-6037. doi: 10.1038/onc.2016.134. Epub 2016 May 9. Oncogene. 2016. PMID: 27157610 Free PMC article.
TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype.
Fessler E, Drost J, van Hooff SR, Linnekamp JF, Wang X, Jansen M, De Sousa E Melo F, Prasetyanti PR, IJspeert JE, Franitza M, Nürnberg P, van Noesel CJ, Dekker E, Vermeulen L, Clevers H, Medema JP. Fessler E, et al. Among authors: van noesel cj, van hooff sr. EMBO Mol Med. 2016 Jul 1;8(7):745-60. doi: 10.15252/emmm.201606184. Print 2016 Jul. EMBO Mol Med. 2016. PMID: 27221051 Free PMC article.
The earliest events in BRAF-mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct progression pathways.
Bleijenberg AG, IJspeert JE, Mulder JB, Drillenburg P, Stel HV, Lodder EM, Carvalho B, Jansen J, Meijer G, van Eeden S, Dekker E, van Noesel CJ. Bleijenberg AG, et al. Among authors: van noesel cj, van eeden s. J Pathol. 2022 Jun;257(2):239-249. doi: 10.1002/path.5881. Epub 2022 Mar 25. J Pathol. 2022. PMID: 35143042 Free PMC article.
A large family with MSH3-related polyposis.
Aelvoet AS, Hoekman DR, Redeker BJW, Weegenaar J, Dekker E, van Noesel CJM, Duijkers FAM. Aelvoet AS, et al. Fam Cancer. 2023 Jan;22(1):49-54. doi: 10.1007/s10689-022-00297-x. Epub 2022 Jun 8. Fam Cancer. 2023. PMID: 35675019 Free PMC article.
162 results