Abu-Elheiga L - Search Results

1

A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M. Kamisuki S, et al. Among authors: abu elheiga l. Chem Biol. 2009 Aug 28;16(8):882-92. doi: 10.1016/j.chembiol.2009.07.007. Chem Biol. 2009. PMID: 19716478 Free article.

2

Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.

Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M. Kamisuki S, et al. Among authors: abu elheiga l. J Med Chem. 2011 Jul 14;54(13):4923-7. doi: 10.1021/jm200304y. Epub 2011 Jun 8. J Med Chem. 2011. PMID: 21561152 Free PMC article.

3

Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule.

Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M. Jung D, et al. Among authors: abu elheiga l. Biochem J. 2012 Dec 15;448(3):409-16. doi: 10.1042/BJ20121158. Biochem J. 2012. PMID: 23067267

4

Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions.

Abu-Elheiga L, Wu H, Gu Z, Bressler R, Wakil SJ. Abu-Elheiga L, et al. J Biol Chem. 2012 Apr 6;287(15):12578-88. doi: 10.1074/jbc.M111.309559. Epub 2012 Feb 23. J Biol Chem. 2012. PMID: 22362781 Free PMC article.

5

Fatty acid metabolism: target for metabolic syndrome.

Wakil SJ, Abu-Elheiga LA. Wakil SJ, et al. Among authors: abu elheiga la. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S138-43. doi: 10.1194/jlr.R800079-JLR200. Epub 2008 Dec 1. J Lipid Res. 2009. PMID: 19047759 Free PMC article. Review.

6

Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets.

Abu-Elheiga L, Oh W, Kordari P, Wakil SJ. Abu-Elheiga L, et al. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10207-12. doi: 10.1073/pnas.1733877100. Epub 2003 Aug 14. Proc Natl Acad Sci U S A. 2003. PMID: 12920182 Free PMC article.

7

Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms.

Abu-Elheiga L, Almarza-Ortega DB, Baldini A, Wakil SJ. Abu-Elheiga L, et al. J Biol Chem. 1997 Apr 18;272(16):10669-77. doi: 10.1074/jbc.272.16.10669. J Biol Chem. 1997. PMID: 9099716 Free article.

8

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.

Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ. Abu-Elheiga L, et al. Science. 2001 Mar 30;291(5513):2613-6. doi: 10.1126/science.1056843. Science. 2001. PMID: 11283375

9

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.

Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Dong B, et al. Among authors: abu elheiga la. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18831-6. doi: 10.1073/pnas.0909731106. Epub 2009 Oct 22. Proc Natl Acad Sci U S A. 2009. PMID: 19850873 Free PMC article.

10

Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis.

Mao J, DeMayo FJ, Li H, Abu-Elheiga L, Gu Z, Shaikenov TE, Kordari P, Chirala SS, Heird WC, Wakil SJ. Mao J, et al. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8552-7. doi: 10.1073/pnas.0603115103. Epub 2006 May 22. Proc Natl Acad Sci U S A. 2006. PMID: 16717184 Free PMC article.

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