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Patients with multidrug-resistant tuberculosis display impaired Th1 responses and enhanced regulatory T-cell levels in response to an outbreak of multidrug-resistant Mycobacterium tuberculosis M and Ra strains.
Geffner L, Yokobori N, Basile J, Schierloh P, Balboa L, Romero MM, Ritacco V, Vescovo M, González Montaner P, Lopez B, Barrera L, Alemán M, Abatte E, Sasiain MC, de la Barrera S. Geffner L, et al. Infect Immun. 2009 Nov;77(11):5025-34. doi: 10.1128/IAI.00224-09. Epub 2009 Aug 31. Infect Immun. 2009. PMID: 19720756 Free PMC article.
Outbreaks of mycobacterium tuberculosis MDR strains induce high IL-17 T-cell response in patients with MDR tuberculosis that is closely associated with high antigen load.
Basile JI, Geffner LJ, Romero MM, Balboa L, Sabio Y García C, Ritacco V, García A, Cuffré M, Abbate E, López B, Barrera L, Ambroggi M, Alemán M, Sasiain MC, de la Barrera SS. Basile JI, et al. Among authors: geffner lj. J Infect Dis. 2011 Oct 1;204(7):1054-64. doi: 10.1093/infdis/jir460. J Infect Dis. 2011. PMID: 21881121
Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy.
Schierloh P, Yokobori N, Alemán M, Landoni V, Geffner L, Musella RM, Castagnino J, Baldini M, Abbate E, de la Barrera SS, Sasiain MC. Schierloh P, et al. Among authors: geffner l. Infect Immun. 2007 Nov;75(11):5325-37. doi: 10.1128/IAI.00381-07. Epub 2007 Aug 20. Infect Immun. 2007. PMID: 17709420 Free PMC article.
Differential induction of macrophage cell death by antigens of a clustered and a non-clustered multidrug-resistant Mycobacterium tuberculosis strain from Haarlem family.
Yokobori N, Sabio y García CA, Geffner L, Schierloh P, López B, Ritacco V, Barrera L, de la Barrera S, del Carmen Saisiain M. Yokobori N, et al. Among authors: geffner l. FEMS Immunol Med Microbiol. 2012 Dec;66(3):363-71. doi: 10.1111/j.1574-695X.2012.01024.x. Epub 2012 Sep 10. FEMS Immunol Med Microbiol. 2012. PMID: 22889125 Free article.
Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models.
Yokobori N, López B, Geffner L, Sabio y García C, Schierloh P, Barrera L, de la Barrera S, Sakai S, Kawamura I, Mitsuyama M, Ritacco V, Sasiain Mdel C. Yokobori N, et al. Among authors: geffner l. Infect Genet Evol. 2013 Jun;16:151-6. doi: 10.1016/j.meegid.2013.01.007. Epub 2013 Jan 24. Infect Genet Evol. 2013. PMID: 23352891
CD3 expression distinguishes two gammadeltaT cell receptor subsets with different phenotype and effector function in tuberculous pleurisy.
Yokobori N, Schierloh P, Geffner L, Balboa L, Romero M, Musella R, Castagnino J, De Stéfano G, Alemán M, de la Barrera S, Abbate E, Sasiain MC. Yokobori N, et al. Among authors: geffner l. Clin Exp Immunol. 2009 Sep;157(3):385-94. doi: 10.1111/j.1365-2249.2009.03974.x. Clin Exp Immunol. 2009. PMID: 19664147 Free PMC article.
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