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Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.
Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM. Scharschmidt TC, et al. Among authors: man mq. J Allergy Clin Immunol. 2009 Sep;124(3):496-506, 506.e1-6. doi: 10.1016/j.jaci.2009.06.046. J Allergy Clin Immunol. 2009. PMID: 19733297 Free PMC article.
Barrier function regulates epidermal DNA synthesis.
Proksch E, Feingold KR, Man MQ, Elias PM. Proksch E, et al. Among authors: man mq. J Clin Invest. 1991 May;87(5):1668-73. doi: 10.1172/JCI115183. J Clin Invest. 1991. PMID: 2022737 Free PMC article.
168 results