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Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.
Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM. Scharschmidt TC, et al. Among authors: wu y. J Allergy Clin Immunol. 2009 Sep;124(3):496-506, 506.e1-6. doi: 10.1016/j.jaci.2009.06.046. J Allergy Clin Immunol. 2009. PMID: 19733297 Free PMC article.
The role of CD44 in cutaneous inflammation.
Man M, Elias PM, Man W, Wu Y, Bourguignon LY, Feingold KR, Man MQ. Man M, et al. Among authors: wu y. Exp Dermatol. 2009 Nov;18(11):962-8. doi: 10.1111/j.1600-0625.2009.00882.x. Epub 2009 Mar 26. Exp Dermatol. 2009. PMID: 19469887 Free PMC article.
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