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Discovery of a novel class of AKT pleckstrin homology domain inhibitors.
Mahadevan D, Powis G, Mash EA, George B, Gokhale VM, Zhang S, Shakalya K, Du-Cuny L, Berggren M, Ali MA, Jana U, Ihle N, Moses S, Franklin C, Narayan S, Shirahatti N, Meuillet EJ. Mahadevan D, et al. Among authors: meuillet ej. Mol Cancer Ther. 2008 Sep;7(9):2621-32. doi: 10.1158/1535-7163.MCT-07-2276. Mol Cancer Ther. 2008. PMID: 18790745 Free PMC article.
Recent development of anticancer therapeutics targeting Akt.
Morrow JK, Du-Cuny L, Chen L, Meuillet EJ, Mash EA, Powis G, Zhang S. Morrow JK, et al. Among authors: meuillet ej. Recent Pat Anticancer Drug Discov. 2011 Jan;6(1):146-59. doi: 10.2174/157489211793980079. Recent Pat Anticancer Drug Discov. 2011. PMID: 21110830 Free PMC article. Review.
Development of sulfonamide AKT PH domain inhibitors.
Ahad AM, Zuohe S, Du-Cuny L, Moses SA, Zhou LL, Zhang S, Powis G, Meuillet EJ, Mash EA. Ahad AM, et al. Among authors: meuillet ej. Bioorg Med Chem. 2011 Mar 15;19(6):2046-54. doi: 10.1016/j.bmc.2011.01.049. Epub 2011 Feb 1. Bioorg Med Chem. 2011. PMID: 21353784 Free PMC article.
Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G. Meuillet EJ, et al. Mol Cancer Ther. 2010 Mar;9(3):706-17. doi: 10.1158/1535-7163.MCT-09-0985. Epub 2010 Mar 2. Mol Cancer Ther. 2010. PMID: 20197390 Free PMC article.
An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors.
Indarte M, Puentes R, Maruggi M, Ihle NT, Grandjean G, Scott M, Ahmed Z, Meuillet EJ, Zang S, Lemos R Jr, Du-Cuny L, Layng FIAL, Correa RG, Bankston LA, Liddington RC, Kirkpatrick L, Powis G. Indarte M, et al. Among authors: meuillet ej. Cancer Res. 2019 Jun 15;79(12):3100-3111. doi: 10.1158/0008-5472.CAN-18-2372. Epub 2019 Apr 30. Cancer Res. 2019. PMID: 31040156 Free PMC article.
61 results