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Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype.
Mancuso DJ, Sims HF, Han X, Jenkins CM, Guan SP, Yang K, Moon SH, Pietka T, Abumrad NA, Schlesinger PH, Gross RW. Mancuso DJ, et al. Among authors: abumrad na. J Biol Chem. 2007 Nov 30;282(48):34611-22. doi: 10.1074/jbc.M707795200. Epub 2007 Oct 8. J Biol Chem. 2007. PMID: 17923475 Free PMC article.
Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation.
Mancuso DJ, Sims HF, Yang K, Kiebish MA, Su X, Jenkins CM, Guan S, Moon SH, Pietka T, Nassir F, Schappe T, Moore K, Han X, Abumrad NA, Gross RW. Mancuso DJ, et al. Among authors: abumrad na. J Biol Chem. 2010 Nov 19;285(47):36495-510. doi: 10.1074/jbc.M110.115766. Epub 2010 Sep 3. J Biol Chem. 2010. PMID: 20817734 Free PMC article.
185 results